9GBE
Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 344 | 38932.8 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | B (A) | NVL-655 | non-polymer | 452.9 | 1 | Chemie (A1IJ8) | |||
| 3 | C (A) | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A: 1069 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1068 | - | expression tag |
| Met 1196 | Leu 1196 | engineered mutation |
| Arg 1202 | Gly 1202 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38932.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 452.9 | |
| All* | Total formula weight | 39385.7 |
