9GAX
TEAD1 in complex with a reversible inhibitor N-[(1S)-2-hydroxy-1-(1-methyl-1H-pyrazol-3-yl)ethyl]-2-methyl-8-[4-(trifluoromethyl)phenyl]-2H,8H-pyrazolo[3,4-b]indole-5-carboxamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcriptional enhancer factor TEF-1 | polymer | 220 | 25461.0 | 2 | UniProt (P28347) Pfam (PF17725) | Homo sapiens (human) | NTEF-1,Protein GT-IIC,TEA domain family member 1,TEAD-1,Transcription factor 13,TCF-13 |
| 2 | C, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D, I (A, B) | 2-methyl-~{N}-[(1~{S})-1-(1-methylpyrazol-3-yl)-2-oxidanyl-ethyl]-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxamide | non-polymer | 482.5 | 2 | Chemie (A1IJL) | |||
| 4 | E, F, G, J, K... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A, B: 207 - 426 (UniProt: P28347)
| PDB | External Database | Details |
|---|---|---|
| Pro 208 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50921.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1725.5 | |
| All* | Total formula weight | 52647.4 |
