Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9G8M

human 80S ribosome bound by a SKI2-exosome complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Helicase SKI2Wpolymer1246137913.71UniProt (Q15477)
Pfam (PF17911)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF21408)
Pfam (PF13234)
Pfam (PF08148)		Homo sapiens (human)Ski2,Helicase-like protein,HLP
2B
(L)		Exosome complex component RRP41polymer24526417.01UniProt (Q9NPD3)
Pfam (PF01138)
Pfam (PF03725)		Homo sapiens (human)Exosome component 4,Ribosomal RNA-processing protein 41,p12A
3C
(N)		Exosome complex component RRP43polymer28030429.91UniProt (Q96B26)
Pfam (PF01138)
Pfam (PF03725)		Homo sapiens (human)Exosome component 8,Opa-interacting protein 2,OIP-2,Ribosomal RNA-processing protein 43,p9
4D
(O)		Exosome complex component RRP46polymer23925636.31UniProt (Q9NQT4)
Pfam (PF01138)
Pfam (PF03725)		Homo sapiens (human)Chronic myelogenous leukemia tumor antigen 28,Exosome component 5,Ribosomal RNA-processing protein 46,p12B
5E
(F)		Exosome complex component RRP42polymer29532216.81UniProt (Q15024)
Pfam (PF01138)
Pfam (PF03725)		Homo sapiens (human)Exosome component 7,Ribosomal RNA-processing protein 42,p8
6F
(G)		Exosome complex component MTR3polymer27228267.11UniProt (Q5RKV6)
Pfam (PF01138)		Homo sapiens (human)Exosome component 6,mRNA transport regulator 3 homolog,hMtr3,p11
7G
(H)		Exosome complex component RRP40,Exosome complex component MTR3polymer37139512.51UniProt (Q9NQT5)
UniProt (Q5RKV6)
Pfam (PF21261)
Pfam (PF21262)
Pfam (PF15985)		Homo sapiens (human)Exosome component 3,Ribosomal RNA-processing protein 40,p10,Exosome component 6,mRNA transport regulator 3 homolog,hMtr3,p11
8H
(I)		Exosome complex component RRP4polymer29733190.41UniProt (Q13868)
Pfam (PF14382)
Pfam (PF21266)
Pfam (PF15985)		Homo sapiens (human)Exosome component 2,Ribosomal RNA-processing protein 4
9I
(J)		Exosome complex component CSL4polymer19921835.11UniProt (Q9Y3B2)
Pfam (PF14382)
Pfam (PF10447)		Homo sapiens (human)Exosome component 1
10J
(K)		Exosome complex component RRP45polymer44349370.31UniProt (Q06265)
Pfam (PF01138)
Pfam (PF03725)		Homo sapiens (human)Autoantigen PM/Scl 1,Exosome component 9,P75 polymyositis-scleroderma overlap syndrome-associated autoantigen,Polymyositis/scleroderma autoantigen 1,Polymyositis/scleroderma autoantigen 75 kDa,PM/Scl-75
11K
(E)		Isoform 2 of HBS1-like proteinpolymer27430196.11UniProt (Q9Y450)Homo sapiens (human)ERFS
12L
(M)		DIS3-like exonuclease 1polymer1096125230.01UniProt (Q8TF46)
Pfam (PF17216)
Pfam (PF17849)
Pfam (PF00773)
Pfam (PF17215)		Homo sapiens (human)
13M
(X)		CrPV-IRES RNApolymer24978988.81Cricket paralysis virus
14N
(S2)		18S ribosomal RNApolymer1869602752.91Homo sapiens
15O
(SA)		40S ribosomal protein SApolymer29532883.91UniProt (P08865)
Pfam (PF00318)
Pfam (PF16122)		Homo sapiens (human)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2
16P
(SB)		40S ribosomal protein S3apolymer26430002.11UniProt (P61247)
Pfam (PF01015)		Homo sapiens (human)Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1
17Q
(SD)		40S ribosomal protein S3polymer24326729.41UniProt (P23396)
Pfam (PF07650)
Pfam (PF00189)		Homo sapiens (human)Small ribosomal subunit protein uS3
18R
(SE)		40S ribosomal protein S4, X isoformpolymer26329654.91UniProt (P62701)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)		Homo sapiens (human)SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4
19S
(SF)		40S ribosomal protein S5polymer20422913.51UniProt (P46782)
Pfam (PF00177)		Homo sapiens (human)Small ribosomal subunit protein uS7
20T
(SH)		40S ribosomal protein S7polymer19422168.91UniProt (P62081)
Pfam (PF01251)		Homo sapiens (human)Small ribosomal subunit protein eS7
21U
(SI)		40S ribosomal protein S8polymer20824263.41UniProt (P62241)
Pfam (PF01201)		Homo sapiens (human)Small ribosomal subunit protein eS8
22V
(SK)		40S ribosomal protein S10polymer16518933.81UniProt (P46783)
Pfam (PF03501)		Homo sapiens (human)Small ribosomal subunit protein eS10
23W
(SL)		40S ribosomal protein S11polymer15818468.81UniProt (P62280)
Pfam (PF16205)
Pfam (PF00366)		Homo sapiens (human)Small ribosomal subunit protein uS17
24X
(SP)		40S ribosomal protein S15polymer14517076.21UniProt (P62841)
Pfam (PF00203)		Homo sapiens (human)RIG protein,Small ribosomal subunit protein uS19
25Y
(SQ)		40S ribosomal protein S16polymer14616477.41UniProt (P62249)
Pfam (PF00380)		Homo sapiens (human)Small ribosomal subunit protein uS9
26Z
(SR)		40S ribosomal protein S17polymer13515578.21UniProt (P08708)
Pfam (PF00833)		Homo sapiens (human)Small ribosomal subunit protein eS17
27AA
(SS)		40S ribosomal protein S18polymer15217759.81UniProt (P62269)
Pfam (PF00416)		Homo sapiens (human)Ke-3,Ke3,Small ribosomal subunit protein uS13
28BA
(ST)		40S ribosomal protein S19polymer14516091.61UniProt (P39019)
Pfam (PF01090)		Homo sapiens (human)Small ribosomal subunit protein eS19
29CA
(SU)		40S ribosomal protein S20polymer11913398.81UniProt (P60866)
Pfam (PF00338)		Homo sapiens (human)Small ribosomal subunit protein uS10
30DA
(SV)		40S ribosomal protein S21polymer839124.41UniProt (P63220)
Pfam (PF01249)		Homo sapiens (human)Small ribosomal subunit protein eS21
31EA
(SX)		40S ribosomal protein S23polymer14315844.71UniProt (P62266)
Pfam (PF00164)		Homo sapiens (human)Small ribosomal subunit protein uS12
32FA
(Sa)		40S ribosomal protein S26polymer11513047.51UniProt (P62854)
Pfam (PF01283)		Homo sapiens (human)Small ribosomal subunit protein eS26
33GA
(Sc)		40S ribosomal protein S28polymer697855.11UniProt (P62857)
Pfam (PF01200)		Homo sapiens (human)Small ribosomal subunit protein eS28
34HA
(Sd)		40S ribosomal protein S29polymer566690.81UniProt (P62273)
Pfam (PF00253)		Homo sapiens (human)Small ribosomal subunit protein uS14
35IA
(Sf)		Ubiquitinpolymer15618004.01UniProt (P62979)
Pfam (PF00240)
Pfam (PF01599)		Homo sapiens (human)
36JA
(Sg)		Receptor of activated protein C kinase 1polymer31735115.71UniProt (P63244)
Pfam (PF00400)		Homo sapiens (human)Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1
37KA
(SC)		40S ribosomal protein S2polymer29331376.51UniProt (P15880)
Pfam (PF00333)
Pfam (PF03719)		Homo sapiens (human)40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5
38LA
(SG)		40S ribosomal protein S6polymer24928751.91UniProt (P62753)
Pfam (PF01092)		Homo sapiens (human)Phosphoprotein NP33,Small ribosomal subunit protein eS6
39MA
(SJ)		40S ribosomal protein S9polymer19422641.61UniProt (P46781)
Pfam (PF00163)
Pfam (PF01479)		Homo sapiens (human)Small ribosomal subunit protein uS4
40NA
(SM)		40S ribosomal protein S12polymer13214548.91UniProt (P25398)
Pfam (PF01248)		Homo sapiens (human)Small ribosomal subunit protein eS12
41OA
(SN)		40S ribosomal protein S13polymer15117259.41UniProt (P62277)
Pfam (PF08069)
Pfam (PF00312)		Homo sapiens (human)Small ribosomal subunit protein uS15
42PA
(SO)		40S ribosomal protein S14polymer15116302.81UniProt (P62263)
Pfam (PF00411)		Homo sapiens (human)Small ribosomal subunit protein uS11
43QA
(SW)		40S ribosomal protein S15apolymer13014865.61UniProt (P62244)
Pfam (PF00410)		Homo sapiens (human)Small ribosomal subunit protein uS8
44RA
(SY)		40S ribosomal protein S24polymer13315463.31UniProt (P62847)
Pfam (PF01282)		Homo sapiens (human)Small ribosomal subunit protein eS24
45SA
(SZ)		40S ribosomal protein S25polymer12513776.21UniProt (P62851)
Pfam (PF03297)		Homo sapiens (human)Small ribosomal subunit protein eS25
46TA
(Sb)		40S ribosomal protein S27polymer849480.21UniProt (P42677)
Pfam (PF01667)		Homo sapiens (human)Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27
47UA
(Se)		40S ribosomal protein S30polymer596668.91UniProt (P62861)
Pfam (PF04758)		Homo sapiens (human)Small ribosomal subunit protein eS30
48VA
(L5)		28S ribosomal RNApolymer50661638937.01Homo sapiens
49WA
(L7)		5S ribosomal RNApolymer12138998.11GenBank (23898)Homo sapiens (human)
50XA
(L8)		5.8S ribosomal RNApolymer15750449.81GenBank (555853)Homo sapiens (human)
51YA
(LA)		60S ribosomal protein L8polymer25728088.91UniProt (P62917)
Pfam (PF00181)
Pfam (PF03947)		Homo sapiens (human)Large ribosomal subunit protein uL2
52ZA
(LB)		60S ribosomal protein L3polymer40346211.11UniProt (P39023)
Pfam (PF00297)		Homo sapiens (human)HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3
53AB
(LC)		60S ribosomal protein L4polymer42747804.61UniProt (P36578)
Pfam (PF00573)
Pfam (PF14374)		Homo sapiens (human)60S ribosomal protein L1,Large ribosomal subunit protein uL4
54BB
(LD)		60S ribosomal protein L5polymer29734426.81UniProt (P46777)
Pfam (PF17144)
Pfam (PF14204)		Homo sapiens (human)Large ribosomal subunit protein uL18
55CB
(LE)		Large ribosomal subunit protein eL6polymer28832810.21UniProt (Q02878)
Pfam (PF03868)
Pfam (PF01159)		Homo sapiens (human)60S ribosomal protein L6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107
56DB
(LF)		Large ribosomal subunit protein uL30polymer24829291.01UniProt (P18124)
Pfam (PF08079)
Pfam (PF00327)		Homo sapiens (human)60S ribosomal protein L7
57EB
(LG)		60S ribosomal protein L7apolymer26630061.81UniProt (P62424)
Pfam (PF01248)		Homo sapiens (human)Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3
58FB
(LH)		60S ribosomal protein L9polymer19221899.51UniProt (P32969)
Pfam (PF00347)		Homo sapiens (human)Large ribosomal subunit protein uL6
59GB
(LI)		Ribosomal protein uL16-likepolymer21424570.91UniProt (Q96L21)
Pfam (PF00252)		Homo sapiens (human)60S ribosomal protein L10-like,Large ribosomal subunit protein uL16-like
60HB
(LJ)		60S ribosomal protein L11polymer17820288.51UniProt (P62913)
Pfam (PF00281)
Pfam (PF00673)		Homo sapiens (human)CLL-associated antigen KW-12,Large ribosomal subunit protein uL5
61IB
(LL)		60S ribosomal protein L13polymer21124321.71UniProt (P26373)
Pfam (PF01294)		Homo sapiens (human)Breast basic conserved protein 1,Large ribosomal subunit protein eL13
62JB
(LM)		60S ribosomal protein L14polymer21523485.01UniProt (P50914)
Pfam (PF01929)		Homo sapiens (human)CAG-ISL 7,Large ribosomal subunit protein eL14
63KB
(LN)		60S ribosomal protein L15polymer20424207.31UniProt (P61313)
Pfam (PF00827)		Homo sapiens (human)Large ribosomal subunit protein eL15
64LB
(LO)		60S ribosomal protein L13apolymer20323633.41UniProt (P40429)
Pfam (PF00572)		Homo sapiens (human)23 kDa highly basic protein,Large ribosomal subunit protein uL13
65MB
(LP)		60S ribosomal protein L17polymer18421443.21UniProt (P18621)
Pfam (PF00237)		Homo sapiens (human)60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1
66NB
(LQ)		60S ribosomal protein L18polymer18821687.71UniProt (Q07020)
Pfam (PF17135)		Homo sapiens (human)Large ribosomal subunit protein eL18
67OB
(LR)		60S ribosomal protein L19polymer19623535.31UniProt (P84098)
Pfam (PF01280)
Pfam (PF25476)		Homo sapiens (human)Large ribosomal subunit protein eL19
68PB
(LS)		60S ribosomal protein L18apolymer17620808.51UniProt (Q02543)
Pfam (PF01775)		Homo sapiens (human)Large ribosomal subunit protein eL20
69QB
(LT)		60S ribosomal protein L21polymer16018610.01UniProt (P46778)
Pfam (PF01157)		Homo sapiens (human)Large ribosomal subunit protein eL21
70RB
(LU)		60S ribosomal protein L22polymer12814813.01UniProt (P35268)
Pfam (PF01776)		Homo sapiens (human)EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22
71SB
(LV)		60S ribosomal protein L23polymer14014892.51UniProt (P62829)
Pfam (PF00238)		Homo sapiens (human)60S ribosomal protein L17,Large ribosomal subunit protein uL14
72TB
(LW)		60S ribosomal protein L24polymer15717825.11UniProt (P83731)
Pfam (PF01246)		Homo sapiens (human)60S ribosomal protein L30,Large ribosomal subunit protein eL24
73UB
(LX)		60S ribosomal protein L23apolymer15617740.21UniProt (P62750)
Pfam (PF03939)
Pfam (PF00276)		Homo sapiens (human)Large ribosomal subunit protein uL23
74VB
(LY)		60S ribosomal protein L26polymer14517303.41UniProt (P61254)
Pfam (PF16906)
Pfam (PF00467)		Homo sapiens (human)Large ribosomal subunit protein uL24
75WB
(LZ)		60S ribosomal protein L27polymer13615835.81UniProt (P61353)
Pfam (PF00467)
Pfam (PF01777)		Homo sapiens (human)Large ribosomal subunit protein eL27
76XB
(La)		60S ribosomal protein L27apolymer14816604.51UniProt (P46776)
Pfam (PF00828)		Homo sapiens (human)Large ribosomal subunit protein uL15
77YB
(Lb)		60S ribosomal protein L29polymer15917804.31UniProt (P47914)
Pfam (PF01779)		Homo sapiens (human)Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29
78ZB
(Lc)		60S ribosomal protein L30polymer11512805.11UniProt (P62888)
Pfam (PF01248)		Homo sapiens (human)Large ribosomal subunit protein eL30
79AC
(Ld)		60S ribosomal protein L31polymer12514494.91UniProt (P62899)
Pfam (PF01198)		Homo sapiens (human)Large ribosomal subunit protein eL31
80BC
(Le)		60S ribosomal protein L32polymer13515898.91UniProt (P62910)
Pfam (PF01655)		Homo sapiens (human)Large ribosomal subunit protein eL32
81CC
(Lf)		60S ribosomal protein L35apolymer11012564.71UniProt (P18077)
Pfam (PF01247)		Homo sapiens (human)Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33
82DC
(Lg)		60S ribosomal protein L34polymer11713326.11UniProt (P49207)
Pfam (PF01199)		Homo sapiens (human)Large ribosomal subunit protein eL34
83EC
(Lh)		60S ribosomal protein L35polymer12314593.61UniProt (P42766)
Pfam (PF00831)		Homo sapiens (human)Large ribosomal subunit protein uL29
84FC
(Li)		60S ribosomal protein L36polymer10512290.91UniProt (Q9Y3U8)
Pfam (PF01158)		Homo sapiens (human)Large ribosomal subunit protein eL36
85GC
(Lj)		60S ribosomal protein L37polymer9711111.01UniProt (P61927)
Pfam (PF01907)		Homo sapiens (human)G1.16,Large ribosomal subunit protein eL37
86HC
(Lk)		60S ribosomal protein L38polymer708238.91UniProt (P63173)
Pfam (PF01781)		Homo sapiens (human)Large ribosomal subunit protein eL38
87IC
(Ll)		60S ribosomal protein L39polymer516426.81UniProt (P62891)
Pfam (PF00832)		Homo sapiens (human)Large ribosomal subunit protein eL39
88JC
(Lm)		Ubiquitin-60S ribosomal protein L40polymer12814758.41UniProt (P62987)
Pfam (PF00240)
Pfam (PF01020)		Homo sapiens (human)CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1
89KC
(Ln)		60S ribosomal protein L41polymer253473.51UniProt (P62945)
Pfam (PF05162)		Homo sapiens (human)HG12,Large ribosomal subunit protein eL41
90LC
(Lo)		60S ribosomal protein L36apolymer10612477.01UniProt (P83881)
Pfam (PF00935)		Homo sapiens (human)60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein,Large ribosomal subunit protein eL42
91MC
(Lp)		60S ribosomal protein L37apolymer9210299.41UniProt (P61513)
Pfam (PF01780)		Homo sapiens (human)Large ribosomal subunit protein eL43
92NC
(Lr)		60S ribosomal protein L28polymer13715784.61UniProt (P46779)
Pfam (PF01778)		Homo sapiens (human)Large ribosomal subunit protein eL28
93AD, AE, AF, AG, AH...
(S2, L5, L8, Sc, LA...)		MAGNESIUM IONnon-polymer24.3232Chemie (MG)
94BF, LL, ML, OL, PL...
(Sa, Lg, Lj, Lm, Lo...)		ZINC IONnon-polymer65.46Chemie (ZN)
Sequence modifications
N: 1 - 276 (UniProt: Q96B26)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Asp -1-expression tag
Ser 0-expression tag
O: 1 - 235 (UniProt: Q9NQT4)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Asp -1-expression tag
Ser 0-expression tag
F: 1 - 291 (UniProt: Q15024)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Asp -1-expression tag
Ser 0-expression tag
H: 1 - 275 (UniProt: Q9NQT5)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Asp -1-expression tag
Ser 0-expression tag
His 61Ser 61conflict
His 225Tyr 225variant
H: 276 - 367 (UniProt: Q5RKV6)
I: 1 - 293 (UniProt: Q13868)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Asp -1-expression tag
Ser 0-expression tag
J: 1 - 195 (UniProt: Q9Y3B2)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Asp -1-expression tag
Ser 0-expression tag
K: 1 - 439 (UniProt: Q06265)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Asp -1-expression tag
Ser 0-expression tag
E: 369 - 632 (UniProt: Q9Y450)
PDBExternal DatabaseDetails
Gly 365-expression tag
Pro 366-expression tag
Asp 367-expression tag
Ser 368-expression tag
Leu 633-expression tag
Glu 634-expression tag
Val 635-expression tag
Leu 636-expression tag
Phe 637-expression tag
Gln 638-expression tag
M: 1 - 1054 (UniProt: Q8TF46)
PDBExternal DatabaseDetails
Met -41-initiating methionine
Ser -40-expression tag
Ala -39-expression tag
Trp -38-expression tag
Ser -37-expression tag
His -36-expression tag
Pro -35-expression tag
Gln -34-expression tag
Phe -33-expression tag
Glu -32-expression tag
Lys -31-expression tag
Gly -30-expression tag
Gly -29-expression tag
Gly -28-expression tag
Ser -27-expression tag
Gly -26-expression tag
Gly -25-expression tag
Gly -24-expression tag
Ser -23-expression tag
Gly -22-expression tag
Gly -21-expression tag
Ser -20-expression tag
Ala -19-expression tag
Trp -18-expression tag
Ser -17-expression tag
His -16-expression tag
Pro -15-expression tag
Gln -14-expression tag
Phe -13-expression tag
Glu -12-expression tag
Lys -11-expression tag
Thr -10-expression tag
Ala -9-expression tag
Gly -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
Asn 486Asp 486conflict
SM: 1 - 132 (UniProt: P25398)
PDBExternal DatabaseDetails
Gln 52Leu 52conflict
Leu 69Cys 69conflict
Asn 99Lys 99conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains92
Total formula weight4438107.4
Non-Polymers*Number of molecules238
Total formula weight6031.2
All*Total formula weight4444138.7
*Water molecules are not included.

250359

PDB entries from 2026-03-11

PDB statisticsPDBj update infoContact PDBjnumon