9G71
Cryo-EM structure of TTYH2 in complex with lipids in GDN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein tweety homolog 2 | polymer | 599 | 66000.0 | 2 | UniProt (Q9BSA4) Pfam (PF04906) | Homo sapiens (human) | hTTY2,Volume-regulated anion channel subunit TTYH2 |
| 2 | C, D, E, F (C, D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | G, H, W, X (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | AA, BA, CA, DA, EA... (B, A) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 17 | Chemie (PLC) | |||
| 5 | FA, GA, K, L, N... (B, A) | CHOLESTEROL | non-polymer | 386.7 | 6 | Chemie (CLR) | |||
| 6 | P, Q, Y (A, B) | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 758.1 | 3 | Chemie (CPL) |
Sequence modifications
A, B: 2 - 534 (UniProt: Q9BSA4)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| Ala 535 | - | expression tag |
| Leu 536 | - | expression tag |
| Glu 537 | - | expression tag |
| Val 538 | - | expression tag |
| Leu 539 | - | expression tag |
| Phe 540 | - | expression tag |
| Gln 541 | - | expression tag |
| Gly 542 | - | expression tag |
| Pro 543 | - | expression tag |
| Gln 544 | - | expression tag |
| Gly 545 | - | expression tag |
| Thr 546 | - | expression tag |
| Glu 547 | - | expression tag |
| Gln 548 | - | expression tag |
| Lys 549 | - | expression tag |
| Leu 550 | - | expression tag |
| Ile 551 | - | expression tag |
| Ser 552 | - | expression tag |
| Glu 553 | - | expression tag |
| Glu 554 | - | expression tag |
| Asp 555 | - | expression tag |
| Leu 556 | - | expression tag |
| Arg 557 | - | expression tag |
| Gly 558 | - | expression tag |
| Ala 559 | - | expression tag |
| Ser 560 | - | expression tag |
| Met 561 | - | expression tag |
| Asp 562 | - | expression tag |
| Glu 563 | - | expression tag |
| Lys 564 | - | expression tag |
| Thr 565 | - | expression tag |
| Thr 566 | - | expression tag |
| Gly 567 | - | expression tag |
| Trp 568 | - | expression tag |
| Arg 569 | - | expression tag |
| Gly 570 | - | expression tag |
| Gly 571 | - | expression tag |
| His 572 | - | expression tag |
| Val 573 | - | expression tag |
| Val 574 | - | expression tag |
| Glu 575 | - | expression tag |
| Gly 576 | - | expression tag |
| Leu 577 | - | expression tag |
| Ala 578 | - | expression tag |
| Gly 579 | - | expression tag |
| Glu 580 | - | expression tag |
| Leu 581 | - | expression tag |
| Glu 582 | - | expression tag |
| Gln 583 | - | expression tag |
| Leu 584 | - | expression tag |
| Arg 585 | - | expression tag |
| Ala 586 | - | expression tag |
| Arg 587 | - | expression tag |
| Leu 588 | - | expression tag |
| Glu 589 | - | expression tag |
| His 590 | - | expression tag |
| His 591 | - | expression tag |
| Pro 592 | - | expression tag |
| Gln 593 | - | expression tag |
| Gly 594 | - | expression tag |
| Gln 595 | - | expression tag |
| Arg 596 | - | expression tag |
| Glu 597 | - | expression tag |
| Pro 598 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 132000.1 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 16067.1 | |
| All* | Total formula weight | 149764.8 |
