9G6A
Peptide-Small Molecule Hybrids as Novel Selective Irreversible Cathepsin-K Inhibitors in Primary Osteoclasts and Human Lung Cancer Tissue
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cathepsin K | polymer | 216 | 23594.6 | 2 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 2 | C, G (A, B) | (2~{S})-4-methyl-~{N}-(2-oxidanylidenepropyl)-2-[[(1~{S})-2,2,2-tris(fluoranyl)-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide | non-polymer | 498.6 | 2 | Chemie (A1IJC) | |||
| 3 | D, E, K (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 4 | F, H, I, J (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 417 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 215 (UniProt: P43235)
| PDB | External Database | Details |
|---|---|---|
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47189.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1607.9 | |
| All* | Total formula weight | 48797.1 |
