9G4S
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 56
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N6-adenosine-methyltransferase catalytic subunit | polymer | 214 | 24656.4 | 1 | UniProt (Q86U44) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N6-adenosine-methyltransferase non-catalytic subunit | polymer | 280 | 32534.0 | 1 | UniProt (Q9HCE5) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | C (A) | 4-[(3~{R})-3-(cyclopropylmethylamino)piperidin-1-yl]-1-[(1~{R})-1-[4-[5-(dimethylamino)pyridin-3-yl]-1,2,3-triazol-1-yl]ethyl]pyridin-2-one | non-polymer | 462.6 | 1 | Chemie (A1III) | |||
| 4 | D, E, F, H, I (A, B) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) | |||
| 5 | G (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
B: 116 - 395 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Leu 273 | Lys 273 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57190.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 785.1 | |
| All* | Total formula weight | 57975.4 |
