9G2E
Cryo-EM structure of the beta3 homomeric GABA(A) receptor in the long-lived desensitised state (C5) sprayed with PBS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 395 | 45643.2 | 5 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3 |
| 2 | F, H, J, L, N (a, b, c, d, e) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 3 | G, I, K, M, O (F, G, H, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | EA, IA, P, V, Z (D, E, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | BA, CA, FA, GA, Q... (D, E, A, B, C) | DECANE | non-polymer | 142.3 | 10 | Chemie (D10) | |||
| 6 | AA, DA, HA, S, W (C, D, E, A, B) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 7 | JA, KA, LA, MA, NA (A, B, C, D, E) | water | water | 18.0 | 455 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 307 (UniProt: P28472)
| PDB | External Database | Details |
|---|---|---|
| Met -53 | - | initiating methionine |
| Asp -52 | - | expression tag |
| Glu -51 | - | expression tag |
| Lys -50 | - | expression tag |
| Thr -49 | - | expression tag |
| Thr -48 | - | expression tag |
| Gly -47 | - | expression tag |
| Trp -46 | - | expression tag |
| Arg -45 | - | expression tag |
| Gly -44 | - | expression tag |
| Gly -43 | - | expression tag |
| His -42 | - | expression tag |
| Val -41 | - | expression tag |
| Val -40 | - | expression tag |
| Glu -39 | - | expression tag |
| Gly -38 | - | expression tag |
| Leu -37 | - | expression tag |
| Ala -36 | - | expression tag |
| Gly -35 | - | expression tag |
| Glu -34 | - | expression tag |
| Leu -33 | - | expression tag |
| Glu -32 | - | expression tag |
| Gln -31 | - | expression tag |
| Leu -30 | - | expression tag |
| Arg -29 | - | expression tag |
| Ala -28 | - | expression tag |
| Arg -27 | - | expression tag |
| Leu -26 | - | expression tag |
| Glu -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| Pro -22 | - | expression tag |
| Gln -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Gln -19 | - | expression tag |
| Arg -18 | - | expression tag |
| Glu -17 | - | expression tag |
| Pro -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Tyr -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Ile -12 | - | expression tag |
| Pro -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 308 | - | expression tag |
| Gln 309 | - | expression tag |
| Pro 310 | - | expression tag |
| Ala 311 | - | expression tag |
| Arg 312 | - | expression tag |
| Ala 313 | - | expression tag |
| Ala 314 | - | expression tag |
| Ala 422 | - | expression tag |
| Ile 423 | - | expression tag |
| Asp 424 | - | expression tag |
| Arg 425 | - | expression tag |
| Trp 426 | - | expression tag |
| Ser 427 | - | expression tag |
| Arg 428 | - | expression tag |
| Ile 429 | - | expression tag |
| Val 430 | - | expression tag |
| Phe 431 | - | expression tag |
| Pro 432 | - | expression tag |
| Phe 433 | - | expression tag |
| Thr 434 | - | expression tag |
| Phe 435 | - | expression tag |
| Ser 436 | - | expression tag |
| Leu 437 | - | expression tag |
| Phe 438 | - | expression tag |
| Asn 439 | - | expression tag |
| Leu 440 | - | expression tag |
| Val 441 | - | expression tag |
| Tyr 442 | - | expression tag |
| Trp 443 | - | expression tag |
| Leu 444 | - | expression tag |
| Tyr 445 | - | expression tag |
| Tyr 446 | - | expression tag |
| Val 447 | - | expression tag |
| Asn 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 228216.2 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 6676.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2706.1 | |
| All* | Total formula weight | 237598.5 |
