9FZV
Structure of cathepsin B1 from Schistosoma mansoni (SmCB1) in complex with a carborane inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Cathepsin B-like peptidase (C01 family) | polymer | 254 | 28507.3 | 3 | UniProt (Q8MNY2) Pfam (PF00112) | Schistosoma mansoni | Cathepsin B1 isotype 1 |
| 2 | D, H, K (A, B, C) | carborane inhibitor | non-polymer | 471.0 | 3 | Chemie (A1IHQ) | |||
| 3 | E, F, G, I, J (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | L, M, N (A, B, C) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A, B, C: 70 - 323 (UniProt: Q8MNY2)
| PDB | External Database | Details |
|---|---|---|
| Ala 168 | Thr 185 | engineered mutation |
| Ala 283 | Thr 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 85521.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1723.2 | |
| All* | Total formula weight | 87245.0 |
