9FSJ
Crystal structure of the HECT domain of Smurf 1 in complex with inhibitor 8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase SMURF1 | polymer | 377 | 43974.3 | 1 | UniProt (Q9HCE7) Pfam (PF00632) | Homo sapiens (human) | hSMURF1,HECT-type E3 ubiquitin transferase SMURF1,SMAD ubiquitination regulatory factor 1,SMAD-specific E3 ubiquitin-protein ligase 1 |
| 2 | B (A) | ethyl 5-[1,3-benzodioxol-5-ylmethyl(ethyl)carbamoyl]-2,4-dimethyl-1~{H}-pyrrole-3-carboxylate | non-polymer | 372.4 | 1 | Chemie (TJQ) | |||
| 3 | C (A) | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence modifications
A: 377 - 751 (UniProt: Q9HCE7)
| PDB | External Database | Details |
|---|---|---|
| Gly 375 | - | expression tag |
| Pro 376 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43974.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 372.4 | |
| All* | Total formula weight | 44346.8 |
