9FR8

Crystal structure of human GSK3B in complex with ARN25565

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glycogen synthase kinase-3 beta	polymer	442	49285.8	2	UniProt (P49841) Pfam (PF00069)	Homo sapiens (human)	GSK-3 beta,Serine/threonine-protein kinase GSK3B
2	C, D (A, B)	~{N}4-(3-cyclobutyl-1~{H}-pyrazol-5-yl)-~{N}2-(pyridin-3-ylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine	non-polymer		377.5	2	Chemie (A1IE7)
3	E, F (A, B)	water	water		18.0	348	Chemie (HOH)

Sequence modifications

A, B: 2 - 420 (UniProt: P49841)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Ser -13	-	expression tag
Ser -12	-	expression tag
Gly -11	-	expression tag
Val -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Gly -7	-	expression tag
Thr -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	98571.6
Non-Polymers*	Number of molecules	2
	Total formula weight	754.9
All*	Total formula weight	99326.5

*Water molecules are not included.