9FON

Cocrystal structure of Drosophila melanogaster TDO with a bound compound

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tryptophan 2,3-dioxygenase	polymer	365	43304.7	2	UniProt (P20351) Pfam (PF03301)	Drosophila melanogaster (fruit fly)	TDO,Protein vermilion,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TO,TRPO,Tryptophan pyrrolase,Tryptophanase
2	C, E (A, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	D, F (A, B)	(~{R})-(7-chloranylimidazo[1,5-a]pyridin-5-yl)-(1-phenyl-1,2,3-triazol-4-yl)methanol	non-polymer		325.8	2	Chemie (A1IER)
4	G, H (A, B)	water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B: 24 - 379 (UniProt: P20351)

PDB	External Database	Details
Met 23	-	initiating methionine
Leu 380	-	expression tag
Glu 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86609.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1884.5
All*	Total formula weight	88493.8

*Water molecules are not included.