9FOE

Crystal structure of the PWWP1 domain of NSD2 bound by compound 7.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-lysine N-methyltransferase NSD2	polymer	174	19085.7	1	UniProt (O96028) Pfam (PF00855)	Homo sapiens (human)	Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein
2	B (A)	1-[[(2~{S})-1-[4-[ethyl(pyridin-4-ylmethyl)amino]-6-methyl-pyrimidin-2-yl]pyrrolidin-2-yl]methyl]urea	non-polymer		369.5	1	Chemie (A1IEF)
3	C (A)	water	water		18.0	38	Chemie (HOH)

Sequence modifications

A: 208 - 368 (UniProt: O96028)

PDB	External Database	Details
Met 204	-	initiating methionine
Gly 205	-	expression tag
Gly 206	-	expression tag
Gly 207	-	expression tag
Ala 256	Lys 256	engineered mutation
Ala 257	Lys 257	engineered mutation
Ala 285	Glu 285	engineered mutation
Ala 291	Glu 291	engineered mutation
Ala 304	Lys 304	engineered mutation
Ala 312	Lys 312	engineered mutation
Ala 351	Asp 351	engineered mutation
Gly 369	-	expression tag
Gly 370	-	expression tag
Gly 371	-	expression tag
Glu 372	-	expression tag
Asn 373	-	expression tag
Leu 374	-	expression tag
Tyr 375	-	expression tag
Phe 376	-	expression tag
Gln 377	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19085.7
Non-Polymers*	Number of molecules	1
	Total formula weight	369.5
All*	Total formula weight	19455.2

*Water molecules are not included.