9FNT

Cryo-EM structure of the P domain of the Hepatitis E Virus ORF2 protein in complex with Fab ES4.431

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Secreted protein ORF2	polymer	486	52886.7	2	UniProt (Q9YLQ9)	Homo sapiens (human)	ORF2s
2	C, E (C, E)	Human IgG antibody Es4.431 -Fab heavy chain	polymer	236	25087.1	2		Homo sapiens
3	D, F (D, F)	Human IgG antibody Es4.431 - Fab light chain	polymer	208	22779.2	2		Homo sapiens
4	G, H (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A, B: 126 - 601 (UniProt: Q9YLQ9)

PDB	External Database	Details
Thr 356	Ala 356	conflict
Phe 500	Leu 500	conflict
Ser 551	Gly 551	conflict
His 602	-	expression tag
His 603	-	expression tag
His 604	-	expression tag
His 605	-	expression tag
His 606	-	expression tag
His 607	-	expression tag
His 608	-	expression tag
His 609	-	expression tag
His 610	-	expression tag
His 611	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	201506.0
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	201948.5

*Water molecules are not included.