9FLQ
Crystal structure of human Haspin (GSG2) kinase bound to MU1959
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein kinase haspin | polymer | 357 | 40711.5 | 1 | UniProt (Q8TF76) Pfam (PF12330) In PDB | Homo sapiens (human) | Germ cell-specific gene 2 protein,H-haspin,Haploid germ cell-specific nuclear protein kinase |
2 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
3 | A | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 5 | Chemie (MPD) | |||
4 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | A | [4-[5-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]pyridin-2-yl]methanamine | non-polymer | 305.3 | 1 | Chemie (A1IDD) | |||
6 | A | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
7 | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 465 - 798 (UniProt: Q8TF76)
PDB | External Database | Details |
---|---|---|
Met 442 | - | initiating methionine |
His 443 | - | expression tag |
His 444 | - | expression tag |
His 445 | - | expression tag |
His 446 | - | expression tag |
His 447 | - | expression tag |
His 448 | - | expression tag |
Ser 449 | - | expression tag |
Ser 450 | - | expression tag |
Gly 451 | - | expression tag |
Val 452 | - | expression tag |
Asp 453 | - | expression tag |
Leu 454 | - | expression tag |
Gly 455 | - | expression tag |
Thr 456 | - | expression tag |
Glu 457 | - | expression tag |
Asn 458 | - | expression tag |
Leu 459 | - | expression tag |
Tyr 460 | - | expression tag |
Phe 461 | - | expression tag |
Gln 462 | - | expression tag |
Ser 463 | - | expression tag |
Met 464 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40711.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1239.2 | |
All* | Total formula weight | 41950.7 |