9FLF
Three-Dimensional Structure of Human Carbonic Anhydrase IX in Complex with a Covalent Inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Carbonic anhydrase | polymer | 256 | 28089.6 | 4 | UniProt (A0A2R9BYT1) Pfam (PF00194) UniProt (by SIFTS) (Q16790) | Homo sapiens (human) | |
| 2 | E, G, I, K (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, H, J, L (A, B, C, D) | 3-[[(1~{R},4~{Z})-cyclododec-4-en-1-yl]amino]-4-ethylsulfonyl-2,5,6-tris(fluoranyl)benzenesulfonamide | non-polymer | 482.6 | 4 | Chemie (A1IDV) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 419 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 4 - 261 (UniProt: A0A2R9BYT1)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Arg 18 | Gln 151 | conflict |
| Ser 41 | Cys 174 | engineered mutation |
| Gln 213 | Asn 346 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112358.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2192.0 | |
| All* | Total formula weight | 114550.3 |
