9FKX
Crystal structure of IL-17A in complex with compound 18
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-17A | polymer | 123 | 14251.1 | 2 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | C (A) | (4~{S})-1-[(~{R})-[2-[(~{S})-[4,4-bis(fluoranyl)cyclohexyl]-[[5-[1,1-bis(fluoranyl)ethyl]-1,3,4-oxadiazol-2-yl]amino]methyl]imidazo[1,2-b]pyridazin-7-yl]-cyclopropyl-methyl]-4-(trifluoromethyl)imidazolidin-2-one | non-polymer | 604.5 | 1 | Chemie (A1IDT) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 155 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | initiating methionine |
| Ser 129 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28502.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 604.5 | |
| All* | Total formula weight | 29106.6 |
