9FIW

MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH LRP6 INTERNALIZATION PEPTIDE SYRHFA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Low-density lipoprotein receptor-related protein 6	polymer	6	756.8	1	UniProt (O75581)	Homo sapiens	LRP-6
2	B (M)	AP-2 complex subunit mu	polymer	286	32889.6	1	UniProt (P84092) Pfam (PF00928)	Rattus norvegicus (Norway rat)	AP-2 mu chain,Adaptor protein complex AP-2 subunit mu,Adaptor-related protein complex 2 subunit mu,Clathrin assembly protein complex 2 mu medium chain,Clathrin coat assembly protein AP50,Clathrin coat-associated protein AP50,Mu2-adaptin,Plasma membrane adaptor AP-2 50 kDa protein

Sequence modifications

A: 369 - 374 (UniProt: O75581)

PDB	External Database	Details
Ala 374	Ser 1521	conflict

M: 158 - 435 (UniProt: P84092)

PDB	External Database	Details
Met 150	-	initiating methionine
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
His 155	-	expression tag
His 156	-	expression tag
Met 157	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33646.4
All*	Total formula weight	33646.4

*Water molecules are not included.