9FIP

Structure-guided discovery of selective USP7 inhibitors with in vivo activity

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ubiquitin carboxyl-terminal hydrolase 7	polymer	355	41148.5	2	UniProt (Q93009) Pfam (PF00443)	Homo sapiens (human)	Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7
2	C, D (A, B)	3-[[4-oxidanyl-1-[(1~{R},2~{R})-2-phenylcyclohexyl]carbonyl-piperidin-4-yl]methyl]quinazolin-4-one	non-polymer		445.6	2	Chemie (A1ICU)
3	E, F (A, B)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A, B: 207 - 560 (UniProt: Q93009)

PDB	External Database	Details
Gly 206	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82296.9
Non-Polymers*	Number of molecules	2
	Total formula weight	891.1
All*	Total formula weight	83188.1

*Water molecules are not included.