9FIO
Structure-guided discovery of selective USP7 inhibitors with in vivo activity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ubiquitin carboxyl-terminal hydrolase 7 | polymer | 355 | 41148.5 | 2 | UniProt (Q93009) Pfam (PF00443) | Homo sapiens (human) | Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7 |
| 2 | C, D (A, B) | 3-({4-hydroxy-1-[(2R)-2-methyl-3-phenylpropanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one | non-polymer | 405.5 | 2 | Chemie (R4D) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A, B: 208 - 560 (UniProt: Q93009)
| PDB | External Database | Details |
|---|---|---|
| Gly 206 | - | expression tag |
| Ser 207 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82296.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 811.0 | |
| All* | Total formula weight | 83107.9 |
