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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9FFZ

Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 in the short-lived asymmetric desensitised 1 state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(A, D)		Gamma-aminobutyric acid receptor subunit alpha-1polymer41147059.62UniProt (P14867)
Pfam (PF02931)
Pfam (PF02932)		Homo sapiens (human)GABA(A) receptor subunit alpha-1,GABAAR subunit alpha-1
2B, E
(B, E)		Gamma-aminobutyric acid receptor subunit beta-3polymer39545643.22UniProt (P28472)
Pfam (PF02931)
Pfam (PF02932)		Homo sapiens (human)GABA(A) receptor subunit beta-3,GABAAR subunit beta-3
3C
(C)		Isoform 1 of Gamma-aminobutyric acid receptor subunit gamma-2polymer37342957.01UniProt (P18507)
Pfam (PF02931)
Pfam (PF02932)		Homo sapiens (human)GABA(A) receptor subunit gamma-2,GABAAR subunit gamma-2
4F
(F)		Nanobody38polymer13314748.21Lama glama
5G
(a)		alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1721.51In PDB
GlyTouCan (G40702WU)
6H, J, L
(b, c, e)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.43In PDB
GlyTouCan (G42666HT)
7I, M
(G, H)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.02In PDB
GlyTouCan (G09724ZC)
8K
(d)		alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched910.81In PDB
GlyTouCan (G22768VO)
9N, Q
(A, E)		GAMMA-AMINO-BUTANOIC ACIDnon-polymer103.12Chemie (ABU)
PubChem (119)
10O
(A)		(19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoatenon-polymer749.01Chemie (D3D)
11P
(B)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
A, D: 5 - 312 (UniProt: P14867)
PDBExternal DatabaseDetails
Met -52-initiating methionine
Asp -51-expression tag
Glu -50-expression tag
Lys -49-expression tag
Thr -48-expression tag
Thr -47-expression tag
Gly -46-expression tag
Trp -45-expression tag
Arg -44-expression tag
Gly -43-expression tag
Gly -42-expression tag
His -41-expression tag
Val -40-expression tag
Val -39-expression tag
Glu -38-expression tag
Gly -37-expression tag
Leu -36-expression tag
Ala -35-expression tag
Gly -34-expression tag
Glu -33-expression tag
Leu -32-expression tag
Glu -31-expression tag
Gln -30-expression tag
Leu -29-expression tag
Arg -28-expression tag
Ala -27-expression tag
Arg -26-expression tag
Leu -25-expression tag
Glu -24-expression tag
His -23-expression tag
His -22-expression tag
Pro -21-expression tag
Gln -20-expression tag
Gly -19-expression tag
Gln -18-expression tag
Arg -17-expression tag
Glu -16-expression tag
Pro -15-expression tag
Asp -14-expression tag
Tyr -13-expression tag
Asp -12-expression tag
Ile -11-expression tag
Pro -10-expression tag
Thr -9-expression tag
Thr -8-expression tag
Glu -7-expression tag
Asn -6-expression tag
Leu -5-expression tag
Tyr -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Thr 0-expression tag
Gly 1-expression tag
Gln 2-expression tag
Pro 3-expression tag
Ser 4-expression tag
A, D: 391 - 429 (UniProt: P14867)
PDBExternal DatabaseDetails
Ser 313-linker
Gln 314-linker
Pro 315-linker
Ala 316-linker
Arg 317-linker
Ala 318-linker
Ala 319-linker
B, E: 1 - 307 (UniProt: P28472)
PDBExternal DatabaseDetails
Met -53-initiating methionine
Asp -52-expression tag
Glu -51-expression tag
Lys -50-expression tag
Thr -49-expression tag
Thr -48-expression tag
Gly -47-expression tag
Trp -46-expression tag
Arg -45-expression tag
Gly -44-expression tag
Gly -43-expression tag
His -42-expression tag
Val -41-expression tag
Val -40-expression tag
Glu -39-expression tag
Gly -38-expression tag
Leu -37-expression tag
Ala -36-expression tag
Gly -35-expression tag
Glu -34-expression tag
Leu -33-expression tag
Glu -32-expression tag
Gln -31-expression tag
Leu -30-expression tag
Arg -29-expression tag
Ala -28-expression tag
Arg -27-expression tag
Leu -26-expression tag
Glu -25-expression tag
His -24-expression tag
His -23-expression tag
Pro -22-expression tag
Gln -21-expression tag
Gly -20-expression tag
Gln -19-expression tag
Arg -18-expression tag
Glu -17-expression tag
Pro -16-expression tag
Asp -15-expression tag
Tyr -14-expression tag
Asp -13-expression tag
Ile -12-expression tag
Pro -11-expression tag
Thr -10-expression tag
Thr -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Thr -1-expression tag
Gly 0-expression tag
B, E: 422 - 448 (UniProt: P28472)
PDBExternal DatabaseDetails
Ser 308-linker
Gln 309-linker
Pro 310-linker
Ala 311-linker
Arg 312-linker
Ala 313-linker
Ala 314-linker
C: 1 - 322 (UniProt: P18507)
PDBExternal DatabaseDetails
Thr -1-expression tag
Gly 0-expression tag
Thr 11Ala 50conflict
C: 400 - 428 (UniProt: P18507)
PDBExternal DatabaseDetails
Ser 323-linker
Gln 324-linker
Pro 325-linker
Ala 326-linker
Arg 327-linker
Ala 328-linker
Gly 429-expression tag
Thr 430-expression tag
Gly 431-expression tag
Gly 432-expression tag
Thr 433-expression tag
Thr 434-expression tag
Glu 435-expression tag
Thr 436-expression tag
Ser 437-expression tag
Gln 438-expression tag
Val 439-expression tag
Ala 440-expression tag
Pro 441-expression tag
Ala 442-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight243111.1
BranchedNumber of molecules7
Total formula weight6051.5
Non-Polymers*Number of molecules4
Total formula weight1341.9
All*Total formula weight250504.4
*Water molecules are not included.

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PDB entries from 2026-05-06

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