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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9FFR

Cryo-EM structure of the alpha1beta3 GABA(A) receptor in complex with GABA and Mb25 in the short-lived asymmetric bound-closed state of branch 2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(D, A)		Gamma-aminobutyric acid receptor subunit alpha-1polymer41147059.62UniProt (P14867)
Pfam (PF02931)
Pfam (PF02932)		Homo sapiens (human)GABA(A) receptor subunit alpha-1
2B, C, E
(E, B, C)		Gamma-aminobutyric acid receptor subunit beta-3polymer39545643.23UniProt (P28472)
Pfam (PF02931)
Pfam (PF02932)		Homo sapiens (human)GABA(A) receptor subunit beta-3
3F
(F)		Megabody25,Outer membrane proteinpolymer52256300.61UniProt (B5Z8H1)
Pfam (PF18304)		Lama glama
4G, H, J, L, M
(a, b, c, d, e)		alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched910.85In PDB
GlyTouCan (G22768VO)
5I, K, N
(G, H, I)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.43In PDB
GlyTouCan (G42666HT)
6O
(D)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
7P, Q
(E, B)		GAMMA-AMINO-BUTANOIC ACIDnon-polymer103.12Chemie (ABU)
PubChem (119)
Sequence modifications
D, A: 5 - 312 (UniProt: P14867)
PDBExternal DatabaseDetails
Met -52-initiating methionine
Asp -51-expression tag
Glu -50-expression tag
Lys -49-expression tag
Thr -48-expression tag
Thr -47-expression tag
Gly -46-expression tag
Trp -45-expression tag
Arg -44-expression tag
Gly -43-expression tag
Gly -42-expression tag
His -41-expression tag
Val -40-expression tag
Val -39-expression tag
Glu -38-expression tag
Gly -37-expression tag
Leu -36-expression tag
Ala -35-expression tag
Gly -34-expression tag
Glu -33-expression tag
Leu -32-expression tag
Glu -31-expression tag
Gln -30-expression tag
Leu -29-expression tag
Arg -28-expression tag
Ala -27-expression tag
Arg -26-expression tag
Leu -25-expression tag
Glu -24-expression tag
His -23-expression tag
His -22-expression tag
Pro -21-expression tag
Gln -20-expression tag
Gly -19-expression tag
Gln -18-expression tag
Arg -17-expression tag
Glu -16-expression tag
Pro -15-expression tag
Asp -14-expression tag
Tyr -13-expression tag
Asp -12-expression tag
Ile -11-expression tag
Pro -10-expression tag
Thr -9-expression tag
Thr -8-expression tag
Glu -7-expression tag
Asn -6-expression tag
Leu -5-expression tag
Tyr -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Thr 0-expression tag
Gly 1-expression tag
Gln 2-expression tag
Pro 3-expression tag
Ser 4-expression tag
D, A: 391 - 429 (UniProt: P14867)
PDBExternal DatabaseDetails
Ser 313-linker
Gln 385-linker
Pro 386-linker
Ala 387-linker
Arg 388-linker
Ala 389-linker
Ala 390-linker
E, B, C: 1 - 307 (UniProt: P28472)
PDBExternal DatabaseDetails
Met -53-initiating methionine
Asp -52-expression tag
Glu -51-expression tag
Lys -50-expression tag
Thr -49-expression tag
Thr -48-expression tag
Gly -47-expression tag
Trp -46-expression tag
Arg -45-expression tag
Gly -44-expression tag
Gly -43-expression tag
His -42-expression tag
Val -41-expression tag
Val -40-expression tag
Glu -39-expression tag
Gly -38-expression tag
Leu -37-expression tag
Ala -36-expression tag
Gly -35-expression tag
Glu -34-expression tag
Leu -33-expression tag
Glu -32-expression tag
Gln -31-expression tag
Leu -30-expression tag
Arg -29-expression tag
Ala -28-expression tag
Arg -27-expression tag
Leu -26-expression tag
Glu -25-expression tag
His -24-expression tag
His -23-expression tag
Pro -22-expression tag
Gln -21-expression tag
Gly -20-expression tag
Gln -19-expression tag
Arg -18-expression tag
Glu -17-expression tag
Pro -16-expression tag
Asp -15-expression tag
Tyr -14-expression tag
Asp -13-expression tag
Ile -12-expression tag
Pro -11-expression tag
Thr -10-expression tag
Thr -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Thr -1-expression tag
Gly 0-expression tag
E, B, C: 422 - 448 (UniProt: P28472)
PDBExternal DatabaseDetails
Ser 308-linker
Gln 309-linker
Pro 310-linker
Ala 311-linker
Arg 312-linker
Ala 313-linker
Ala 314-linker
F: 2 - 13 (PDB: 9FFR)
F: 14 - 234 (UniProt: B5Z8H1)
F: 235 - 403 (UniProt: B5Z8H1)
F: 404 - 523 (PDB: 9FFR)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight287349.7
BranchedNumber of molecules8
Total formula weight5827.3
Non-Polymers*Number of molecules3
Total formula weight592.9
All*Total formula weight293769.9
*Water molecules are not included.

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PDB entries from 2026-04-01

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