9FF0
Cryo-EM structure of the beta3 homomeric GABA(A) receptor in complex with HSM in the short-lived asymmetric open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 338 | 39217.3 | 5 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3 |
| 2 | F, H, J, L, N (a, b, c, d, e) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 3 | G, I, K, M, O (F, G, H, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | P, S, U, W, Y (A, B, C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | Q, R, T, V, X (A, B, C, D, E) | HISTAMINE | non-polymer | 111.1 | 5 | Chemie (HSM) |
Sequence modifications
A, B, C, D, E: 4 - 307 (UniProt: P28472)
A, B, C, D, E: 422 - 448 (UniProt: P28472)
A, B, C, D, E: 422 - 448 (UniProt: P28472)
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 309 | - | linker |
| Pro 310 | - | linker |
| Ala 311 | - | linker |
| Arg 312 | - | linker |
| Ala 313 | - | linker |
| Ala 314 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 196086.5 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 6676.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1661.8 | |
| All* | Total formula weight | 204424.4 |
