9F8A
Crystal structure of human monoacylglycerol lipase in complex with compound 7a
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Monoglyceride lipase | polymer | 323 | 35465.5 | 1 | UniProt (Q99685) Pfam (PF12146) | Homo sapiens (human) | MGL,HU-K5,Lysophospholipase homolog,Lysophospholipase-like,Monoacylglycerol lipase,MAGL |
| 2 | B (A) | 6-[4-(phenylmethyl)piperidin-1-yl]carbonyl-4~{H}-1,4-benzoxazin-3-one | non-polymer | 350.4 | 1 | Chemie (A1IA0) | |||
| 3 | C (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | D (A) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A: 1 - 303 (UniProt: Q99685)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 36 | Lys 36 | engineered mutation |
| Ser 169 | Leu 169 | engineered mutation |
| Ser 176 | Leu 176 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35465.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 373.4 | |
| All* | Total formula weight | 35838.9 |
