9F7S
SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-K229R mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Replicase polyprotein 1ab | polymer | 325 | 36926.8 | 1 | UniProt (P0DTD1) Pfam (PF08715) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, E (A) | MALONATE ION | non-polymer | 102.0 | 2 | Chemie (MLI) | |||
| 4 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | F, G, H (A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 6 | I, J (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | K (A) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
A: 2 - 319 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Ser 112 | Cys 1674 | engineered mutation |
| Asp 191 | Lys 1753 | engineered mutation |
| Arg 229 | Lys 1791 | engineered mutation |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
| His 324 | - | expression tag |
| His 325 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36926.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 515.5 | |
| All* | Total formula weight | 37442.3 |
