9F41
Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with cholesterol bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NPC intracellular sterol transporter 1-related protein 1 | polymer | 248 | 27809.8 | 4 | UniProt (Q12200) Pfam (PF16414) | Saccharomyces cerevisiae (brewer's yeast) | Niemann-Pick type C-related protein 1 |
| 2 | E, N (E, N) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G91845HM) | |||
| 3 | F, O (F, O) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 4 | G (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G68668TB) | |||
| 5 | H (H) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G47410OF) | |||
| 6 | I, L (I, K) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 7 | J, M, P (J, L, P) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 8 | K (M) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G94106MV) | |||
| 9 | BB, CA, MA, Q (D, B, C, A) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 10 | AA, AB, BA, CB, DA... (A, C, D, B) | ZINC ION | non-polymer | 65.4 | 26 | Chemie (ZN) | |||
| 11 | EB, FB, IA, JA, JB... (D, B, C, A) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 12 | T, V (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
| 13 | SA, TA, U, UA, W (C, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) | |||
| 14 | LB, MB, NB, OB (A, B, C, D) | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 245 (UniProt: Q12200)
| PDB | External Database | Details |
|---|---|---|
| Val 246 | - | expression tag |
| Pro 247 | - | expression tag |
| Arg 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111239.2 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 11740.6 | |
| Non-Polymers* | Number of molecules | 47 |
| Total formula weight | 4974.8 | |
| All* | Total formula weight | 127954.6 |
