9F40
Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with ergosterol bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NPC intracellular sterol transporter 1-related protein 1 | polymer | 248 | 27809.8 | 4 | UniProt (Q12200) Pfam (PF16414) | Saccharomyces cerevisiae (brewer's yeast) | Niemann-Pick type C-related protein 1 |
| 2 | E, N (E, N) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G16404YH) | |||
| 3 | F, O (F, O) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 4 | G (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 5 | H, K (H, K) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G47410OF) | |||
| 6 | I, J, P (I, J, P) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 7 | L (L) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 8 | M (M) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | FA, OB, Q, UA (B, D, A, C) | ERGOSTEROL | non-polymer | 396.6 | 4 | Chemie (ERG) PubChem (16394547) PubChem (16403935) PubChem (16405182) PubChem (21139765) PubChem (5996) PubChem (21775588) PubChem (22298561) PubChem (177562045) PubChem (247705) PubChem (439550) PubChem (40469696) PubChem (40469697) PubChem (40469698) PubChem (40469699) PubChem (40826225) PubChem (40826226) PubChem (444679) PubChem (1742286) PubChem (45044427) PubChem (481705) PubChem (638020) PubChem (46936866) PubChem (53298316) PubChem (57182145) PubChem (57508500) PubChem (58992544) PubChem (59373909) PubChem (59738932) PubChem (60113883) PubChem (66824684) PubChem (69866435) PubChem (70544775) PubChem (5317174) PubChem (5319551) PubChem (71073084) PubChem (5351178) PubChem (5351845) PubChem (71122427) PubChem (69473585) PubChem (6428692) PubChem (6432563) PubChem (6433143) PubChem (6436872) PubChem (86575818) PubChem (6452576) PubChem (101703) PubChem (6713013) PubChem (6713713) PubChem (7067891) PubChem (7067892) PubChem (7067893) PubChem (7067894) PubChem (7094294) PubChem (90690511) PubChem (90690567) PubChem (9843722) PubChem (91171783) PubChem (91345764) PubChem (91375317) PubChem (91459231) PubChem (9908757) PubChem (9930654) PubChem (9940587) PubChem (643780) PubChem (10982177) PubChem (11014783) PubChem (11269488) PubChem (12304304) PubChem (12304306) PubChem (12304309) PubChem (12304314) PubChem (12304315) PubChem (5771570) PubChem (6475768) PubChem (122700025) PubChem (124099377) PubChem (124421304) PubChem (102514697) PubChem (10250169) PubChem (117749797) PubChem (121358225) PubChem (123930382) PubChem (12304302) PubChem (124303809) PubChem (124351226) PubChem (124427258) PubChem (124488022) PubChem (124897130) PubChem (124897142) PubChem (124897144) PubChem (124897147) PubChem (124918943) PubChem (124918944) PubChem (124928616) PubChem (124928617) PubChem (125033743) PubChem (125033744) PubChem (125126218) PubChem (125126219) PubChem (126626805) PubChem (126727349) PubChem (126727350) PubChem (129316836) PubChem (129630206) PubChem (131632336) PubChem (142431933) PubChem (134279700) PubChem (163000929) PubChem (163000920) PubChem (163000938) PubChem (164664366) PubChem (142281730) PubChem (145082804) PubChem (146230523) PubChem (154496532) PubChem (171157824) PubChem (161146965) PubChem (162645168) PubChem (163000919) PubChem (163000921) PubChem (163000922) PubChem (163000923) PubChem (163000924) PubChem (163000925) PubChem (163000926) PubChem (163000927) PubChem (163000928) PubChem (163000930) PubChem (163000931) PubChem (163000932) PubChem (163000933) PubChem (163000934) PubChem (163000935) PubChem (163000936) PubChem (163000937) PubChem (163000939) PubChem (163524814) PubChem (171154016) PubChem (175800618) | |||
| 10 | EA, GA, MB, PB, R... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 11 | AC, BA, CA, HA, HB... (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 29 | Chemie (ZN) | |||
| 12 | AB, BB, CB, DA, DB... (C, A, B, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 12 | Chemie (PEG) PubChem (8117) | |||
| 13 | AA, EB, FB, GB, PA... (A, C, B, D) | ACETONITRILE | non-polymer | 41.1 | 9 | Chemie (CCN) PubChem (6342) | |||
| 14 | BC, CC, DC, EC (A, B, C, D) | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 245 (UniProt: Q12200)
| PDB | External Database | Details |
|---|---|---|
| Val 246 | - | expression tag |
| Pro 247 | - | expression tag |
| Arg 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111239.2 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 10929.9 | |
| Non-Polymers* | Number of molecules | 63 |
| Total formula weight | 5990.9 | |
| All* | Total formula weight | 128160.0 |
