9F40
Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with ergosterol bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | NPC intracellular sterol transporter 1-related protein 1 | polymer | 248 | 27809.8 | 4 | UniProt (Q12200) Pfam (PF16414) In PDB | Saccharomyces cerevisiae (brewer's yeast) | Niemann-Pick type C-related protein 1 |
| 2 | E, N | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G16404YH) | |||
| 3 | F, O | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 4 | G | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 5 | H, K | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G47410OF) | |||
| 6 | I, J, P | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 7 | L | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 8 | M | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | B, D, A, C | ERGOSTEROL | non-polymer | 396.6 | 4 | Chemie (ERG) | |||
| 10 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 11 | D, A, B, C | ZINC ION | non-polymer | 65.4 | 29 | Chemie (ZN) | |||
| 12 | C, A, B, D | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 12 | Chemie (PEG) | |||
| 13 | A, C, B, D | ACETONITRILE | non-polymer | 41.1 | 9 | Chemie (CCN) | |||
| 14 | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 245 (UniProt: Q12200)
| PDB | External Database | Details |
|---|---|---|
| Val 246 | - | expression tag |
| Pro 247 | - | expression tag |
| Arg 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111239.2 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 10929.9 | |
| Non-Polymers* | Number of molecules | 63 |
| Total formula weight | 5990.9 | |
| All* | Total formula weight | 128160.0 |
