9F2O
Structure of human carbonic anhydrase XII complexed with 3-(cyclooctylamino)-2,6-difluoro-4-((3-hydroxypropyl)sulfonyl)-5- methoxybenzenesulfonamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Carbonic anhydrase 12 | polymer | 263 | 29917.3 | 4 | UniProt (O43570) Pfam (PF00194) | Homo sapiens (human) | Carbonate dehydratase XII,Carbonic anhydrase XII,CA-XII,Tumor antigen HOM-RCC-3.1.3 |
| 2 | E, L, R, Z (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | AA, BA, CA, DA, EA... (D, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 4 | FA, J, P, X (D, A, B, C) | 3-(cyclooctylamino)-2,6-difluoro-4-((3-hydroxypropyl)sulfonyl)-5- methoxybenzenesulfonamide | non-polymer | 470.6 | 4 | Chemie (A1H89) | |||
| 5 | K, Y (A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 6 | Q (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | GA, HA, IA, JA (A, B, C, D) | water | water | 18.0 | 1292 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 263 (UniProt: O43570)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119669.3 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 3461.4 | |
| All* | Total formula weight | 123130.7 |
