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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9F1C

Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(AH)		mRNApolymer3543.31Oryctolagus cuniculus (rabbit)
2B
(Bb)		60S ribosomal protein L29polymer24526721.71UniProt (G1SGR6)
Pfam (PF01779)		Oryctolagus cuniculus (rabbit)
3C
(B7)		5S rRNApolymer12038691.91GenBank (4CXE_4)Oryctolagus cuniculus (rabbit)
4D
(AT)		P-site tRNApolymer7615209.51Oryctolagus cuniculus (rabbit)
5E
(Ar)		Small ribosomal subunit protein uS13polymer15117670.61UniProt (G1TPG3)
Pfam (PF00416)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S18
6F
(B8)		5.8S rRNApolymer15850809.01GenBank (GBCN01009604.1)Oryctolagus cuniculus (rabbit)
7G
(BU)		60S ribosomal protein L22polymer12814756.91UniProt (G1TSG1)
Pfam (PF01776)		Oryctolagus cuniculus (rabbit)
8H
(As)		40S ribosomal protein S19polymer14516104.61UniProt (G1TN62)
Pfam (PF01090)		Oryctolagus cuniculus (rabbit)
9I
(BA)		Large ribosomal subunit protein uL2polymer25728103.91UniProt (G1TT27)
Pfam (PF00181)
Pfam (PF03947)		Oryctolagus cuniculus (rabbit)60S ribosomal protein L8
10J
(BV)		Ribosomal protein L23polymer14014892.51UniProt (G1T6D1)
Pfam (PF00238)		Oryctolagus cuniculus (rabbit)
11K
(At)		Small ribosomal subunit protein uS10polymer11913398.81UniProt (G1SIZ2)
Pfam (PF00338)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S20
12L
(BB)		Ribosomal protein L3polymer40346121.01UniProt (G1TL06)
Pfam (PF00297)		Oryctolagus cuniculus (rabbit)
13M
(BX)		Ribosomal_L23eN domain-containing proteinpolymer15617768.21UniProt (G1SE76)
Pfam (PF03939)
Pfam (PF00276)		Oryctolagus cuniculus (rabbit)uL23
14N
(Au)		Small ribosomal subunit protein eS21polymer839181.41UniProt (G1TM82)
Pfam (PF01249)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S21
15O
(BC)		Large ribosomal subunit protein uL4polymer41246299.71UniProt (G1SVW5)
Pfam (PF00573)
Pfam (PF14374)		Oryctolagus cuniculus (rabbit)60S ribosomal protein L4
16P
(BP)		Large ribosomal subunit protein uL22polymer18421444.21UniProt (G1SCJ6)
Pfam (PF00237)		Oryctolagus cuniculus (rabbit)60S ribosomal protein L17
17Q
(BZ)		60S ribosomal protein L27polymer13615835.81UniProt (G1TXF6)
Pfam (PF00467)
Pfam (PF01777)		Oryctolagus cuniculus (rabbit)
18R
(Aw)		40S ribosomal protein S23polymer14315860.71UniProt (G1SZ47)
Pfam (PF00164)		Oryctolagus cuniculus (rabbit)
19S
(BE)		60S ribosomal protein L6polymer29133028.31UniProt (G1SKF7)
Pfam (PF03868)
Pfam (PF01159)		Oryctolagus cuniculus (rabbit)
20T
(B5)		28S rRNApolymer48081557519.51GenBank (GBCN01009604.1)Oryctolagus cuniculus (rabbit)
21U
(BQ)		Large ribosomal subunit protein eL18polymer18821699.71Oryctolagus cuniculus (rabbit)
22V
(Ba)		60S ribosomal protein L27apolymer14816635.61UniProt (G1SNY0)
Pfam (PF00828)		Oryctolagus cuniculus (rabbit)
23W
(Ax)		40S ribosomal protein S24polymer13015107.91UniProt (G1T3D8)
Pfam (PF01282)		Oryctolagus cuniculus (rabbit)
24X
(BF)		Ribosomal Protein uL30polymer24729201.81UniProt (G1TUB1)
Pfam (PF08079)
Pfam (PF00327)		Oryctolagus cuniculus (rabbit)
25Y
(BY)		Ribosomal protein L26polymer14517303.41UniProt (G1SQH0)
Pfam (PF16906)
Pfam (PF00467)		Oryctolagus cuniculus (rabbit)
26Z
(BW)		Ribosomal protein L24polymer15717825.11UniProt (G1SE28)
Pfam (PF01246)		Oryctolagus cuniculus (rabbit)eL24
27AA
(AZ)		Small ribosomal subunit protein uS2polymer29432838.81UniProt (G1TLT8)
Pfam (PF00318)
Pfam (PF16122)		Oryctolagus cuniculus (rabbit)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
28BA
(Ay)		40S ribosomal protein S25polymer12413645.01UniProt (G1TDB3)
Pfam (PF03297)		Oryctolagus cuniculus (rabbit)
29CA
(BG)		60S ribosomal protein L7apolymer26630061.81Oryctolagus cuniculus (rabbit)
30DA
(Av)		Ribosomal protein S15apolymer13014865.61UniProt (G1TG89)
Pfam (PF00410)		Oryctolagus cuniculus (rabbit)
31EA
(BR)		Ribosomal protein L19polymer19623535.31UniProt (G1TJR3)
Pfam (PF01280)		Oryctolagus cuniculus (rabbit)
32FA
(Aa)		40S ribosomal protein S3apolymer26430002.11UniProt (G1SS70)
Pfam (PF01015)		Oryctolagus cuniculus (rabbit)RPS3A
33GA
(Az)		60S ribosomal protein L41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)		Oryctolagus cuniculus (rabbit)
34HA
(BH)		60S ribosomal protein L9polymer19221871.41UniProt (G1SWI6)
Pfam (PF00347)		Oryctolagus cuniculus (rabbit)
35IA
(BS)		Large ribosomal subunit protein eL20polymer17620749.41UniProt (G1TTY7)
Pfam (PF01775)		Oryctolagus cuniculus (rabbit)60S ribosomal protein L18a
36JA
(Ab)		Small ribosomal subunit protein uS5polymer29331285.41Oryctolagus cuniculus (rabbit)
37KA
(Bc)		60S ribosomal protein L30polymer11512807.11UniProt (G1TDL2)
Pfam (PF01248)		Oryctolagus cuniculus (rabbit)eL30
38LA
(BI)		60S ribosomal protein L10polymer21424643.11UniProt (B7NZQ2)
Pfam (PF00252)		Oryctolagus cuniculus (rabbit)Ribosomal protein L10
39MA
(B)		Large ribosomal subunit protein uL18polymer29734481.81UniProt (G1SZF4)
Pfam (PF17144)
Pfam (PF14204)		Oryctolagus cuniculus (rabbit)uL18
40NA
(EA)		Methionine aminopeptidase 1polymer38643274.21UniProt (P53582)
Pfam (PF15801)
Pfam (PF00557)		Homo sapiens (human)MAP 1,MetAP 1,Peptidase M 1
41OA
(Ac)		40S ribosomal protein S3polymer28131146.61UniProt (G1TNM3)
Pfam (PF07650)
Pfam (PF00189)		Oryctolagus cuniculus (rabbit)uS3
42PA
(Bd)		60S ribosomal protein L31polymer12514494.91UniProt (G1SHG0)
Pfam (PF01198)		Oryctolagus cuniculus (rabbit)eL31
43QA
(BJ)		60S ribosomal protein L11polymer17820288.51UniProt (G1TUB8)
Pfam (PF00281)
Pfam (PF00673)		Oryctolagus cuniculus (rabbit)
44RA
(Ct)		Nascent polypeptide-associated complex subunit alphapolymer23825857.51UniProt (Q13765)
Pfam (PF01849)
Pfam (PF19026)		Homo sapiens (human)NAC-alpha,Alpha-NAC
45SA
(Ad)		40S ribosomal protein S4polymer26329654.91UniProt (G1TK17)
Pfam (PF08071)
Pfam (PF00900)
Pfam (PF00467)
Pfam (PF16121)		Oryctolagus cuniculus (rabbit)
46TA
(Be)		Ribosomal protein L32polymer13515898.91UniProt (A0AAA9WVN6)Oryctolagus cuniculus (rabbit)
47UA
(BK)		Nascent chainpolymer322741.41Oryctolagus cuniculus (rabbit)
48VA
(Cu)		Transcription factor BTF3polymer16217724.01UniProt (P20290)
Pfam (PF01849)		Homo sapiens (human)Nascent polypeptide-associated complex subunit beta,NAC-beta,RNA polymerase B transcription factor 3
49WA
(Ae)		Ribosomal protein S5polymer20422913.51UniProt (G1TFM5)
Pfam (PF00177)		Oryctolagus cuniculus (rabbit)
50XA
(Bf)		60S ribosomal protein L35apolymer11012580.81UniProt (G1SF08)
Pfam (PF01247)		Oryctolagus cuniculus (rabbit)eL33
51YA
(BL)		Large ribosomal subunit protein eL13polymer21124331.71UniProt (G1TKB3)
Pfam (PF01294)		Oryctolagus cuniculus (rabbit)60S ribosomal protein L13
52ZA
(DA)		Glutathione S-transferase class-mu 26 kDa isozyme,N-alpha-acetyltransferase 50polymer40346529.71UniProt (P08515)
UniProt (Q9GZZ1)
Pfam (PF14497)
Pfam (PF00583)
Pfam (PF02798)		Schistosoma japonicumGST 26,Sj26 antigen,SjGST,hNaa50p,N-acetyltransferase 13,N-acetyltransferase 5,hNAT5,N-acetyltransferase san homolog,hSAN,N-epsilon-acetyltransferase 50,NatE catalytic subunit
53AB
(Af)		40S ribosomal protein S6polymer24928751.91UniProt (G1TM55)
Pfam (PF01092)		Oryctolagus cuniculus (rabbit)
54BB
(Bg)		60S ribosomal protein L34polymer11713326.11UniProt (G1TXG5)
Pfam (PF01199)		Oryctolagus cuniculus (rabbit)
55CB
(BM)		60S ribosomal protein L14polymer21823870.51UniProt (G1SZ12)
Pfam (PF01929)		Oryctolagus cuniculus (rabbit)
56DB
(DB)		N-alpha-acetyltransferase 15, NatA auxiliary subunitpolymer915106506.31UniProt (Q9BXJ9)
Pfam (PF13181)
Pfam (PF12569)		Homo sapiens (human)Gastric cancer antigen Ga19,N-terminal acetyltransferase,NMDA receptor-regulated protein 1,Protein tubedown-1,Tbdn100
57EB
(Ag)		40S ribosomal protein S7polymer43247356.21UniProt (G1SVB0)Oryctolagus cuniculus (rabbit)
58FB
(Bh)		60S ribosomal protein L35polymer12314566.61UniProt (G1SIT5)
Pfam (PF00831)		Oryctolagus cuniculus (rabbit)uL29
59GB
(BN)		Ribosomal protein L15polymer20424207.31UniProt (G1T0C1)
Pfam (PF00827)		Oryctolagus cuniculus (rabbit)
60HB
(DC)		N-alpha-acetyltransferase 10polymer23526479.61UniProt (P41227)
Pfam (PF00583)		Homo sapiens (human)N-terminal acetyltransferase complex ARD1 subunit homolog A,hARD1,NatA catalytic subunit Naa10
61IB
(Ah)		40S ribosomal protein S8polymer20824263.41UniProt (G1TJW1)
Pfam (PF01201)		Oryctolagus cuniculus (rabbit)
62JB
(Bi)		60S ribosomal protein L36polymer10512263.81UniProt (G1TTQ5)
Pfam (PF01158)		Oryctolagus cuniculus (rabbit)
63KB
(BO)		Large ribosomal subunit protein uL13polymer20323533.31UniProt (G1TVS8)Oryctolagus cuniculus (rabbit)60S ribosomal protein L13a
64LB
(A2)		18S rRNApolymer1870603928.31GenBank (GBCT01000564.1)Oryctolagus cuniculus (rabbit)
65MB
(Ai)		40S ribosomal protein S9polymer19422641.61UniProt (B7NZS8)
Pfam (PF00163)
Pfam (PF01479)		Oryctolagus cuniculus (rabbit)
66NB
(Bj)		Ribosomal protein L37polymer9711111.01UniProt (U3KPD5)
Pfam (PF01907)		Oryctolagus cuniculus (rabbit)
67OB
(AA)		40S ribosomal protein S27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)		Oryctolagus cuniculus (rabbit)
68PB
(Aj)		S10_plectin domain-containing proteinpolymer16518933.81UniProt (G1TPV3)
Pfam (PF03501)		Oryctolagus cuniculus (rabbit)eS10
69QB
(Bk)		60S ribosomal protein L38polymer708238.91UniProt (G1U001)
Pfam (PF01781)		Oryctolagus cuniculus (rabbit)eL38
70RB
(AB)		40S ribosomal protein S28polymer697855.11UniProt (G1TIB4)
Pfam (PF01200)		Oryctolagus cuniculus (rabbit)
71SB
(Ak)		40S ribosomal protein S11polymer15818468.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)		Oryctolagus cuniculus (rabbit)
72TB
(Bl)		60S ribosomal protein L39-likepolymer516455.81UniProt (G1TTN1)
Pfam (PF00832)		Oryctolagus cuniculus (rabbit)eL39
73UB
(AC)		Ribosomal protein S27apolymer15618004.01UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)		Oryctolagus cuniculus (rabbit)
74VB
(Al)		40S ribosomal protein S12polymer13214539.01UniProt (G1SFR8)
Pfam (PF01248)		Oryctolagus cuniculus (rabbit)
75WB
(Bm)		Large ribosomal subunit protein eL40polymer12814800.51UniProt (P0DXC2)Oryctolagus cuniculus (rabbit)60S ribosomal protein L40
76XB
(AD)		40S ribosomal protein S30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)		Oryctolagus cuniculus (rabbit)
77YB
(Am)		40S ribosomal protein S13polymer15117259.41UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)		Oryctolagus cuniculus (rabbit)uS15
78ZB
(Bo)		Large ribosomal subunit protein eL42polymer10612490.01UniProt (A0AAA9WX15)Oryctolagus cuniculus (rabbit)
79AC
(AE)		Small ribosomal subunit protein eS26polymer11513047.51Oryctolagus cuniculus (rabbit)
80BC
(An)		Small ribosomal subunit protein uS11polymer15116302.81UniProt (A0AAA9WYR1)Oryctolagus cuniculus (rabbit)
81CC
(Bp)		60S ribosomal protein L37apolymer9210299.41UniProt (G1SY53)
Pfam (PF01780)		Oryctolagus cuniculus (rabbit)eL43
82DC
(AF)		Small ribosomal subunit protein RACK1polymer31735115.71UniProt (G1SJB4)
Pfam (PF00400)		Oryctolagus cuniculus (rabbit)RACK1
83EC
(Ao)		40S ribosomal protein uS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)		Oryctolagus cuniculus (rabbit)
84FC
(Br)		Large ribosomal subunit protein eL28polymer13615713.51UniProt (G1U7L1)
Pfam (PF01778)		Oryctolagus cuniculus (rabbit)60S ribosomal protein L28
85GC
(AG)		40S ribosomal protein S29polymer566690.81UniProt (G1U7M4)
Pfam (PF00253)		Oryctolagus cuniculus (rabbit)uS14
86HC
(Ap)		Small ribosomal subunit protein uS9polymer17219213.51UniProt (G1SGX4)
Pfam (PF00380)		Oryctolagus cuniculus (rabbit)uS9
87IC
(Bs)		60S acidic ribosomal protein P0polymer31834380.51UniProt (G1SPK4)
Pfam (PF00466)
Pfam (PF17777)
Pfam (PF00428)		Oryctolagus cuniculus (rabbit)uL10
88JC
(BT)		60S ribosomal protein L21polymer16018610.01UniProt (G1SHQ2)
Pfam (PF01157)		Oryctolagus cuniculus (rabbit)eL21
89KC
(Aq)		40S ribosomal protein eS17polymer13515552.11UniProt (G1TU13)
Pfam (PF00833)		Oryctolagus cuniculus (rabbit)
90LC
(Bt)		60S ribosomal protein L12polymer16517847.61UniProt (G1SMR7)
Pfam (PF03946)
Pfam (PF00298)		Oryctolagus cuniculus (rabbit)
91AAA, ACA, AD, ADA, AEA...
(A2, B7, B5, BB, BQ...)		UNKNOWN ATOM OR IONnon-polymer277Chemie (UNX)
92ABA, AE, AG, AH, AI...
(A2, BV, B5, BB, B7...)		MAGNESIUM IONnon-polymer24.3420Chemie (MG)
93ZC
(B7)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
94AV, BJ, CEA, DO, DR...
(B5, A2)		SPERMIDINEnon-polymer145.230Chemie (SPD)
95IZ, VP, ZF
(A2, B5)		SPERMINEnon-polymer202.33Chemie (SPM)
96JEA, NEA, OEA, PEA, REA...
(Bj, AC, Bm, Bo, AE...)		ZINC IONnon-polymer65.48Chemie (ZN)
97UX
(DB)		INOSITOL HEXAKISPHOSPHATEnon-polymer660.01Chemie (IHP)
98AFA, AGA, BFA, BGA, CFA...
(B7, Af, AT, Bg, Ar...)		waterwater18.02117Chemie (HOH)
Sequence modifications
BU: 1 - 128 (UniProt: G1TSG1)
PDBExternal DatabaseDetails
Gly 32Arg 32variant
Ala 36Glu 36variant
Phe 39Ser 39variant
Gly 54Arg 54variant
Arg 97His 97variant
As: 1 - 145 (UniProt: G1TN62)
PDBExternal DatabaseDetails
Gly 119Trp 119variant
Asn 142Lys 142variant
B5: 1 - 4808 (GenBank: GBCN01009604.1)
PDBExternal DatabaseDetails
Uy1 3550U 5943conflict
BF: 1 - 247 (UniProt: G1TUB1)
PDBExternal DatabaseDetails
Arg 61Gly 61variant
Arg 93Gly 93variant
Met 131Val 131variant
Ile 153Val 153variant
BR: 1 - 196 (UniProt: G1TJR3)
PDBExternal DatabaseDetails
Arg 38Cys 38variant
Arg 64Gln 64variant
Thr 94Lys 94variant
B: 1 - 297 (UniProt: G1SZF4)
PDBExternal DatabaseDetails
Ser 176Gly 176variant
Arg 248Gln 248variant
EA: 1 - 386 (UniProt: P53582)
PDBExternal DatabaseDetails
Asn 220Asp 220engineered mutation
Ct: 1 - 215 (UniProt: Q13765)
PDBExternal DatabaseDetails
Met -22-initiating methionine
Gly -21-expression tag
Ser -20-expression tag
Ser -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
Ser -12-expression tag
Ser -11-expression tag
Gly -10-expression tag
Leu -9-expression tag
Glu -8-expression tag
Val -7-expression tag
Leu -6-expression tag
Phe -5-expression tag
Gln -4-expression tag
Gly -3-expression tag
Pro -2-expression tag
Ser -1-expression tag
Gly 0-expression tag
Ad: 1 - 263 (UniProt: G1TK17)
PDBExternal DatabaseDetails
Gly 25Ser 25variant
Arg 51Lys 51variant
Thr 78Ala 78variant
Val 156Met 156variant
BL: 1 - 211 (UniProt: G1TKB3)
PDBExternal DatabaseDetails
Arg 74His 74variant
Arg 190His 190variant
DA: -233 - -16 (UniProt: P08515)
PDBExternal DatabaseDetails
Gly -15-linker
Ser -14-linker
Gly -13-linker
Ser -12-linker
Gly -11-linker
Ser -10-linker
Glu -9-linker
Asn -8-linker
Leu -7-linker
Tyr -6-linker
Phe -5-linker
Gln -4-linker
Gly -3-linker
Ala -2-linker
Met -1-linker
Val 0-linker
DA: 1 - 169 (UniProt: Q9GZZ1)
DB: 1 - 866 (UniProt: Q9BXJ9)
PDBExternal DatabaseDetails
Met -48-initiating methionine
Gly -47-expression tag
Ser -46-expression tag
Ser -45-expression tag
His -44-expression tag
His -43-expression tag
His -42-expression tag
His -41-expression tag
His -40-expression tag
His -39-expression tag
Ser -38-expression tag
Ser -37-expression tag
Gly -36-expression tag
Leu -35-expression tag
Val -34-expression tag
Pro -33-expression tag
Arg -32-expression tag
Gly -31-expression tag
Ser -30-expression tag
His -29-expression tag
Met -28-expression tag
Ala -27-expression tag
Ser -26-expression tag
Met -25-expression tag
Thr -24-expression tag
Gly -23-expression tag
Gly -22-expression tag
Gln -21-expression tag
Gln -20-expression tag
Met -19-expression tag
Gly -18-expression tag
Arg -17-expression tag
Ala -16-expression tag
Arg -15-expression tag
Gly -14-expression tag
Ile -13-expression tag
Gln -12-expression tag
Arg -11-expression tag
Pro -10-expression tag
Thr -9-expression tag
Ser -8-expression tag
Thr -7-expression tag
Ser -6-expression tag
Ser -5-expression tag
Leu -4-expression tag
Val -3-expression tag
Ala -2-expression tag
Ala -1-expression tag
Ala 0-expression tag
DC: 1 - 235 (UniProt: P41227)
PDBExternal DatabaseDetails
Gln 24Glu 24engineered mutation
Phe 26Tyr 26engineered mutation
Ah: 1 - 208 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47variant
A2: 1 - 1870 (GenBank: GBCT01000564.1)
PDBExternal DatabaseDetails
B8n 1249C 3623conflict
4ac 1338C 3712conflict
4ac 1843C 4217conflict
Bk: 1 - 70 (UniProt: G1U001)
PDBExternal DatabaseDetails
Lys 24Asn 24variant
An: 1 - 151 (UniProt: A0AAA9WYR1)
PDBExternal DatabaseDetails
Ias 138Asp 155conflict
Br: 2 - 137 (UniProt: G1U7L1)
PDBExternal DatabaseDetails
Arg 103His 103conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains90
Total formula weight4083084.6
Non-Polymers*Number of molecules740
Total formula weight16879.0
All*Total formula weight4099963.5
*Water molecules are not included.

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PDB entries from 2025-06-11

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