9F02

HIV-1 envelope glycoprotein (BG505 gp140 SOSIP.664) trimer in complex with three copies of ELC07 broadly neutralizing antibody.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, E (A, F, E)	Transmembrane protein gp41	polymer	170	19103.6	3	UniProt (Q2N0S8) Pfam (PF00517)	Human immunodeficiency virus 1	TM,Glycoprotein 41,gp41
2	B, C, L (C, G, N)	Envelope glycoprotein gp160	polymer	516	57946.0	3	UniProt (Q2N0S8) Pfam (PF00516)	Human immunodeficiency virus 1	Env polyprotein
3	F, H, J (H, I, K)	ELC07 heavy chain	polymer	268	28586.1	3		Homo sapiens
4	G, I, K (L, J, M)	ELC07 light chain	polymer	235	25599.8	3		Homo sapiens
5	GA, IA, M (d, g, e)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G81315DD)
6	HA, JA, N (f, h, q)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
7	AA, BA, CA, DA, EA... (X, Y, Z, a, b...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	18	In PDB GlyTouCan (G42666HT)
8	AB, BB, CB, DB, EB... (N, C, G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	24	Chemie (NAG)

Sequence modifications

A, F, E: 512 - 664 (UniProt: Q2N0S8)

PDB	External Database	Details
Pro 559	Ile 558	conflict
Cys 605	Thr 604	conflict
Gly 665	-	expression tag
Ser 666	-	expression tag
Gly 667	-	expression tag
Leu 668	-	expression tag
Asn 669	-	expression tag
Asp 670	-	expression tag
Ile 671	-	expression tag
Phe 672	-	expression tag
Glu 673	-	expression tag
Ala 674	-	expression tag
Gln 675	-	expression tag
Lys 676	-	expression tag
Ile 677	-	expression tag
Glu 678	-	expression tag
Trp 679	-	expression tag
His 680	-	expression tag
Glu 681	-	expression tag

C, G, N: 31 - 513 (UniProt: Q2N0S8)

PDB	External Database	Details
Met -4	-	initiating methionine
Asp -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Lys 0	-	expression tag
Arg 1	-	expression tag
Gly 2	-	expression tag
Leu 3	-	expression tag
Cys 4	-	expression tag
Cys 5	-	expression tag
Val 6	-	expression tag
Leu 7	-	expression tag
Leu 8	-	expression tag
Leu 9	-	expression tag
Cys 10	-	expression tag
Gly 11	-	expression tag
Ala 12	-	expression tag
Val 13	-	expression tag
Phe 14	-	expression tag
Val 15	-	expression tag
Ser 16	-	expression tag
Pro 17	-	expression tag
Ser 18	-	expression tag
Gln 19	-	expression tag
Glu 20	-	expression tag
Ile 21	-	expression tag
His 22	-	expression tag
Ala 23	-	expression tag
Arg 24	-	expression tag
Phe 25	-	expression tag
Arg 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ala 29	-	expression tag
Arg 30	-	expression tag
Glu 62	Lys 61	variant
Asn 99	Ser 98	variant
Lys 117	Glu 116	variant
-	Asn 133	deletion
-	Val 134	deletion
Val 134	Thr 135	variant
Thr 135	Asn 136	variant
Asn 136	Ala 137	variant
Arg 185	Ser 184	variant
Asn 185	Lys 186	variant
Asn 185	Ser 187	variant
Asn 234	Thr 235	variant
Pro 240	Ser 241	variant
Ser 241	Asn 242	variant
Arg 308	His 309	variant
Asp 325	Asn 325	variant
His 330	Gln 330	variant
Asn 332	Thr 332	variant
Gly 343	Glu 343	variant
Lys 351	Glu 351	variant
Ile 358	Thr 358	variant
Arg 360	Ile 360	variant
Asn 363	Ser 363	variant
Gly 409	Glu 408	variant
Asn 411	Ser 410	variant
Ser 413	Thr 412	variant
Thr 461	Asn 460	variant
Thr 465	Asn 464	variant
Cys 501	Ala 500	conflict
Arg 509	Glu 508	conflict
Arg 510	Lys 509	conflict
Arg 512	Ala 511	conflict
Arg 513	Val 512	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	393706.2
Branched	Number of molecules	24
	Total formula weight	11644.9
Non-Polymers*	Number of molecules	24
	Total formula weight	5309.0
All*	Total formula weight	410660.1

*Water molecules are not included.