9EZ6
Complex of a mutant of the SARS-CoV-2 main protease Mpro with the nsp14/15 substrate peptide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Replicase polyprotein 1a | polymer | 306 | 33758.4 | 2 | UniProt (A0A8B1KJN1) Pfam (PF05409) UniProt (by SIFTS) (A0A6C1F1G5) | Severe acute respiratory syndrome coronavirus 2 | ORF1a polyprotein |
| 2 | C (C) | THR-PHE-THR-ARG-LEU-GLN-SER-LEU-GLU-ASN | polymer | 11 | 1350.5 | 1 | UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | |
| 3 | D, F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | E, G, H, I, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 5 | J, M (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 6 | Q, V (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | S (B) | GLUTAMINE | non-polymer | 146.1 | 1 | Chemie (GLN) | |||
| 8 | W, X, Y (A, B, C) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 306 (UniProt: A0A8B1KJN1)
| PDB | External Database | Details |
|---|---|---|
| Ala 41 | His 3304 | conflict |
| Ala 145 | Cys 3408 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68867.3 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1305.4 | |
| All* | Total formula weight | 70172.8 |
