9EZ4
Complex of a mutant of the SARS-CoV-2 main protease Mpro with the nsp5/6 substrate peptide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Replicase polyprotein 1a | polymer | 306 | 33774.4 | 1 | UniProt (A0A8B1KJN1) Pfam (PF05409) UniProt (by SIFTS) (A0A6C1F1G5) | Severe acute respiratory syndrome coronavirus 2 | ORF1a polyprotein |
| 2 | B (B) | Non-structural protein 7 | polymer | 306 | 33726.4 | 1 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | nsp7 |
| 3 | C (C) | GLY-VAL-THR-PHE-GLN-SER-ALA-VAL | polymer | 11 | 1181.3 | 1 | UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | |
| 4 | D, E, F, G, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | H, J (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 6 | K (B) | GLUTAMINE | non-polymer | 146.1 | 1 | Chemie (GLN) | |||
| 7 | L, M, N (A, B, C) | water | water | 18.0 | 325 | Chemie (HOH) |
Sequence modifications
A: 1 - 306 (UniProt: A0A8B1KJN1)
B: 1 - 306 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 41 | His 3304 | conflict |
| Ala 145 | Cys 3408 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 41 | His 3304 | conflict |
| Ala 145 | Cys 3408 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68682.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 668.7 | |
| All* | Total formula weight | 69350.9 |
