9EY4
The FK1 domain of FKBP51 in complex with (3S,11S)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 128 | 14004.0 | 1 | UniProt (Q13451) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP5,51 kDa FK506-binding protein,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase |
| 2 | B (A) | (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxamide | non-polymer | 472.4 | 1 | Chemie (A1H78) | |||
| 3 | C (A) | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A: 6 - 130 (UniProt: Q13451)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Pro 5 | - | expression tag |
| Thr 9 | Ala 19 | engineered mutation |
| Ala 93 | Cys 103 | engineered mutation |
| Ile 97 | Cys 107 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14004.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 472.4 | |
| All* | Total formula weight | 14476.4 |
