9EXW
Crystal structure of the PWWP1 domain of NSD2 bound by compound 17.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase NSD2 | polymer | 174 | 19478.2 | 2 | UniProt (O96028) Pfam (PF00855) | Homo sapiens (human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein |
| 2 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | E, F (A, B) | 7-[3-methyl-5-[2-methyl-5-[(pyridin-3-ylamino)methyl]phenyl]imidazol-4-yl]-4~{H}-1,4-benzoxazin-3-one | non-polymer | 425.5 | 2 | Chemie (A1H7X) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A, B: 208 - 368 (UniProt: O96028)
| PDB | External Database | Details |
|---|---|---|
| Met 204 | - | initiating methionine |
| Gly 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Gly 207 | - | expression tag |
| Gly 369 | - | expression tag |
| Gly 370 | - | expression tag |
| Gly 371 | - | expression tag |
| Glu 372 | - | expression tag |
| Asn 373 | - | expression tag |
| Leu 374 | - | expression tag |
| Tyr 375 | - | expression tag |
| Phe 376 | - | expression tag |
| Gln 377 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38956.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 975.1 | |
| All* | Total formula weight | 39931.5 |
