9EWS
Optimisation of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 332 | 37774.6 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 1-[3-pyridin-4-yl-2-[3-(2-pyrimidin-2-ylethynyl)phenyl]-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one | non-polymer | 420.5 | 1 | Chemie (A1H7N) | |||
| 3 | C, D, E, F, G... (A) | IODIDE ION | non-polymer | 126.9 | 15 | Chemie (IOD) | |||
| 4 | R (A) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A: 695 - 1025 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | expression tag |
| Gly 773 | - | insertion |
| Asn 774 | - | insertion |
| Pro 775 | - | insertion |
| Arg 951 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37774.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2324.0 | |
| All* | Total formula weight | 40098.6 |
