9EU0
Crystal structure of Danio rerio HDAC6 CD2 in complex with hydrolyzed DFMO-inhibitor (ITF7209)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone deacetylase 6 | polymer | 365 | 40342.5 | 2 | UniProt (F8W4B7) Pfam (PF00850) | Danio rerio (zebrafish) | |
| 2 | C, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, I, J (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | F (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 5 | G, K (A, B) | ~{N}'-[2,2-bis(fluoranyl)ethanoyl]-5-[(4-~{tert}-butyl-1,2,3-triazol-1-yl)methyl]thiophene-2-carbohydrazide | non-polymer | 357.4 | 2 | Chemie (A1H7I) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 389 | Chemie (HOH) |
Sequence modifications
A, B: 440 - 798 (UniProt: F8W4B7)
| PDB | External Database | Details |
|---|---|---|
| Gly 434 | - | cloning artifact |
| Ser 435 | - | cloning artifact |
| Asn 436 | - | cloning artifact |
| Ala 437 | - | cloning artifact |
| Gly 438 | - | cloning artifact |
| Gly 439 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80685.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1240.3 | |
| All* | Total formula weight | 81925.3 |
