9ESP

CDK2-cyclin A in complex with FragLite 26

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cyclin-dependent kinase 2	polymer	302	34354.8	2	UniProt (P24941) Pfam (PF00069)	Homo sapiens (human)	Cell division protein kinase 2,p33 protein kinase
2	B, D (B, D)	Cyclin-A2	polymer	268	30817.5	2	UniProt (P30274) Pfam (PF00134) Pfam (PF02984)	Bos taurus (cattle)	Cyclin-A
3	E, F, G (A, B, C)	4-bromo-1-(2-methoxyethyl)-1H-pyrazole	non-polymer		205.1	3	Chemie (UUV)
4	H, I, J, K (A, B, C, D)	water	water		18.0	339	Chemie (HOH)

Sequence modifications

A, C: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, D: 172 - 432 (UniProt: P30274)

PDB	External Database	Details
Gly 171	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130344.5
Non-Polymers*	Number of molecules	3
	Total formula weight	615.2
All*	Total formula weight	130959.6

*Water molecules are not included.