9EMJ

SARS-CoV-2 methyltransferase nsp10-16 in complex with Toyocamycin and m7GpppA (Cap0-analog)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	2'-O-methyltransferase nsp16	polymer	303	33912.8	1	UniProt (P0DTD1) Pfam (PF06460)	Severe acute respiratory syndrome coronavirus 2	Non-structural protein 16,nsp16
2	B (B)	Non-structural protein 10	polymer	140	14860.0	1	UniProt (P0DTD1) Pfam (PF09401)	Severe acute respiratory syndrome coronavirus 2	nsp10,Growth factor-like peptide,GFL
3	C (A)	4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	non-polymer		291.3	1	Chemie (TO1)
4	D (A)	P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE	non-polymer		787.4	1	Chemie (GTA)
5	E (A)	7-METHYL-GUANOSINE-5'-TRIPHOSPHATE	non-polymer		538.2	1	Chemie (MGP)
6	F, I (B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7	G, H (B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8	J, K (A, B)	water	water		18.0	365	Chemie (HOH)

Sequence modifications

A: 6799 - 7096 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 6797	-	expression tag
Asn 6798	-	expression tag
Glu 7097	-	expression tag
Asn 7098	-	expression tag
Leu 7099	-	expression tag

B: 4254 - 4392 (UniProt: P0DTD1)

PDB	External Database	Details
Gly 4253	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48772.8
Non-Polymers*	Number of molecules	7
	Total formula weight	1871.9
All*	Total formula weight	50644.7

*Water molecules are not included.