9EMJ

SARS-CoV-2 methyltransferase nsp10-16 in complex with Toyocamycin and m7GpppA (Cap0-analog)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	2'-O-methyltransferase nsp16	polymer	303	33912.8	1	UniProt (P0DTD1) Pfam (PF06460)	Severe acute respiratory syndrome coronavirus 2	Non-structural protein 16,nsp16
2	B (B)	Non-structural protein 10	polymer	140	14860.0	1	UniProt (P0DTD1) Pfam (PF09401)	Severe acute respiratory syndrome coronavirus 2	nsp10,Growth factor-like peptide,GFL
3	C (A)	4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	non-polymer		291.3	1	Chemie (TO1) PubChem (20056711) PubChem (44330599) PubChem (52940199) PubChem (247955) PubChem (71229307) PubChem (59882477) PubChem (67534283) PubChem (67534285) PubChem (70828678) PubChem (512290) PubChem (86308417) PubChem (11824) PubChem (92228413) PubChem (92228414) PubChem (92228415) PubChem (6713009) PubChem (10379505) PubChem (12444444) PubChem (135035806) PubChem (142650216) PubChem (162967177)
4	D (A)	P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE	non-polymer		787.4	1	Chemie (GTA)
5	E (A)	7-METHYL-GUANOSINE-5'-TRIPHOSPHATE	non-polymer		538.2	1	Chemie (MGP)
6	F, I (B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7	G, H (B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8	J, K (A, B)	water	water		18.0	365	Chemie (HOH)

Sequence modifications

A: 6799 - 7096 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 6797	-	expression tag
Asn 6798	-	expression tag
Glu 7097	-	expression tag
Asn 7098	-	expression tag
Leu 7099	-	expression tag

B: 4254 - 4392 (UniProt: P0DTD1)

PDB	External Database	Details
Gly 4253	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48772.8
Non-Polymers*	Number of molecules	7
	Total formula weight	1871.9
All*	Total formula weight	50644.7

*Water molecules are not included.