9EKU
(+)ML-SI3 bound TRPML1-V432A/A433G in a pre-open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mucolipin-1 | polymer | 588 | 66039.9 | 4 | UniProt (Q9GZU1) Pfam (PF21381) Pfam (PF08016) | Homo sapiens (human) | ML1,MG-2,Mucolipidin,Transient receptor potential channel mucolipin 1,TRPML1 |
| 2 | E, F, G, H (A, B, C, D) | N-{(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide | non-polymer | 429.6 | 4 | Chemie (ZB4) |
Sequence modifications
A, B, C, D: 2 - 580 (UniProt: Q9GZU1)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
| Ala 432 | Val 432 | engineered mutation |
| Gly 433 | Ala 433 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 264159.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1718.3 | |
| All* | Total formula weight | 265877.8 |
