9EKO

A chimeric hybrid protein fused with the FGFR3 Transmembrane Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	chimeric protein fused with the FGFR3 Transmembrane Domain,Saposin-A,Fibroblast growth factor receptor 3	polymer	481	52725.2	1	UniProt (P0AEX9) UniProt (P07602) UniProt (P22607)	Homo sapiens (human)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Protein A,FGFR-3
2	B (B)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)
3	C (A)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A: 3 - 363 (UniProt: P0AEX9)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Asp 174	Glu 198	engineered mutation
Ala 182	Asp 206	engineered mutation
Ala 186	Asp 210	engineered mutation
Val 314	Ala 338	engineered mutation
Ala 337	Gln 361	engineered mutation
Tyr 340	Ala 364	engineered mutation
Ala 364	-	linker
Cys 365	-	linker
Ala 366	-	linker
Ile 367	-	linker
Cys 368	-	linker
Leu 369	-	linker
Ile 370	-	linker
Val 371	-	linker
Val 372	-	linker
Ala 373	-	linker
Lys 374	-	linker
Ala 375	-	linker
Gly 376	-	linker
Val 377	-	linker
Met 378	-	linker
Leu 379	-	linker
Arg 380	-	linker

A: 381 - 441 (UniProt: P07602)

PDB	External Database	Details
Asn 442	-	linker
Ser 443	-	linker
Gly 444	-	linker
Gly 445	-	linker
Ser 446	-	linker

A: 447 - 475 (UniProt: P22607)

PDB	External Database	Details
Ser 472	Cys 396	engineered mutation
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52725.2
Branched	Number of molecules	1
	Total formula weight	342.3
All*	Total formula weight	53067.5

*Water molecules are not included.