9EK0

Human M5 muscarinic acetylcholine receptor complex with mini-Gq and iperoxo

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	Muscarinic acetylcholine receptor M5	polymer	343	39190.1	1	UniProt (P08912) Pfam (PF00001)	Homo sapiens (human)
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	350	38534.1	1	UniProt (P54311) Pfam (PF00400)	Rattus norvegicus (Norway rat)	Transducin beta chain 1
3	C (A)	Guanine nucleotide-binding protein Gq alpha subunit chimera	polymer	245	28039.8	1		Homo sapiens
4	D (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	68	7563.8	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
5	E (R)	4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium	non-polymer		197.3	1	Chemie (IXO)

Sequence modifications

R: 2 - 421 (UniProt: P08912)

PDB	External Database	Details
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Ala 1	-	expression tag

R: 422 - 521 (UniProt: P08912)
B: 2 - 340 (UniProt: P54311)

PDB	External Database	Details
Met -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113327.7
Non-Polymers*	Number of molecules	1
	Total formula weight	197.3
All*	Total formula weight	113524.9

*Water molecules are not included.