9EJZ
Human M5 muscarinic acetylcholine receptor complex with mini-Gq, agonist acetylcholine and positive allosteric modulator VU6007678
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (N) | nanobody 35 | polymer | 156 | 16926.1 | 1 | Lama glama | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (A) | Guanine nucleotide-binding protein Gq chimera | polymer | 245 | 28039.8 | 1 | Homo sapiens | ||
| 5 | E (H) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
| 6 | F (R) | Human M5 muscarinic acetylcholine receptor | polymer | 343 | 39190.1 | 1 | Homo sapiens | ||
| 7 | G (R) | VU6007678 | non-polymer | 484.6 | 1 | Chemie (A1BKS) | |||
| 8 | H (R) | ACETYLCHOLINE | non-polymer | 146.2 | 1 | Chemie (ACH) | |||
| 9 | I, J, K, L, M (N, B, A, H, R) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158038.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 630.8 | |
| All* | Total formula weight | 158669.4 |
