9EHL
Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | HIV-1 BG505 SOSIP gp120,Envelope glycoprotein gp120 | polymer | 506 | 56518.3 | 3 | UniProt (Q2N0S5) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | D, E, F (D, E, F) | HIV-1 BG505 SOSIP gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S5) Pfam (PF00517) UniProt (by SIFTS) (D0PUM0) | Human immunodeficiency virus 1 | |
| 3 | G, H, I (G, H, I) | IOMAmin5 Fab Heavy Chain | polymer | 128 | 14347.2 | 3 | Homo sapiens (human) | ||
| 4 | J, K, L (J, K, L) | IOMAmin5 Fab Light Chain | polymer | 111 | 11540.7 | 3 | Homo sapiens (human) | ||
| 5 | M, N, O (M, N, O) | 10-1074 Fab Heavy Chain | polymer | 134 | 14878.5 | 3 | Homo sapiens (human) | ||
| 6 | P, Q, R (P, Q, R) | 10-1074 Fab Light Chain | polymer | 110 | 12089.4 | 3 | Homo sapiens (human) | ||
| 7 | BA, FA, IA, KA, NA... (b, f, i, k, n...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 9 | In PDB GlyTouCan (G15407YE) | |||
| 8 | CA, EA, GA, LA, OA... (c, e, g, l, o...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 9 | DA, HA, U (d, h, U) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 10 | MA, V (m, V) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G31886NL) | |||
| 11 | Z (Z) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 12 | AA, JA (a, j) | alpha-D-mannopyranose-(1-2)-beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB | |||
| 13 | SA (s) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 14 | AB, BB, CB, DB, EB... (B, C, D, E, F...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 27 | Chemie (NAG) |
Sequence modifications
A, B, C: 6 - 32 (PDB: 9EHL)
A, B, C: 33 - 508 (UniProt: Q2N0S5)
D, E, F: 512 - 664 (UniProt: Q2N0S5)
A, B, C: 33 - 508 (UniProt: Q2N0S5)
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
| Arg 509 | - | insertion |
| Arg 510 | - | insertion |
| Arg 511 | - | insertion |
| Arg 512 | - | insertion |
| Arg 513 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 379561.9 | |
| Branched | Number of molecules | 27 |
| Total formula weight | 16647.3 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 5972.6 | |
| All* | Total formula weight | 402181.9 |
