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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9EGZ

RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		DNA-directed RNA polymerase subunitpolymer1984219049.51UniProt (A0A7M4DUC2)
Pfam (PF04997)
Pfam (PF05001)
Pfam (PF00623)
Pfam (PF04983)
Pfam (PF05000)
Pfam (PF04998)
Pfam (PF04992)
Pfam (PF04990)		Sus scrofa (pig)
2B
(B)		DNA-directed RNA polymerase subunit betapolymer1251142426.11UniProt (A0A4X1TVZ5)
Pfam (PF04563)
Pfam (PF04561)
Pfam (PF04565)
Pfam (PF04566)
Pfam (PF04567)
Pfam (PF00562)
Pfam (PF04560)
UniProt (by SIFTS) (A0A0B8RVL1)		Sus scrofa (pig)
3C
(C)		DNA-directed RNA polymerase II subunit RPB3polymer27531439.11UniProt (A0A481DF93)
Pfam (PF01193)
Pfam (PF01000)
UniProt (by SIFTS) (I3LCH3)		Sus scrofa (pig)
4D
(D)		RNA polymerase Rpb4/RPC9 core domain-containing proteinpolymer14216331.31UniProt (A0A8D0KES4)Sus scrofa (pig)
5E
(E)		DNA-directed RNA polymerase II subunit Epolymer21024644.31UniProt (A0A4X1VTX4)
Pfam (PF03871)
Pfam (PF01191)
UniProt (by SIFTS) (I3LSI7)		Sus scrofa (pig)RPB5
6F
(F)		DNA-directed RNA polymerases I, II, and III subunit RPABC2polymer12714477.01UniProt (A0A4X1VEK9)
Pfam (PF01192)		Sus scrofa (pig)DNA-directed RNA polymerase II subunit F,RPB6 homolog
7G
(G)		DNA-directed RNA polymerase II subunit RPB7polymer17219314.31UniProt (A0A4X1VKG7)
Pfam (PF03876)
Pfam (PF00575)		Sus scrofa (pig)
8H
(H)		DNA-directed RNA polymerases I, II, and III subunit RPABC3polymer15017162.31UniProt (A0A8D1AQR7)
Pfam (PF03870)		Sus scrofa (pig)
9I
(I)		DNA-directed RNA polymerase II subunit RPB9polymer12514541.21UniProt (P60899)
Pfam (PF02150)
Pfam (PF01096)		Sus scrofa (pig)RNA polymerase II subunit B9,DNA-directed RNA polymerase II subunit I,RNA polymerase II 14.5 kDa subunit,RPB14.5
10J
(J)		DNA-directed RNA polymerases I, II, and III subunit RPABC5polymer677655.11UniProt (A0A8W4F9W9)
Pfam (PF01194)		Sus scrofa (pig)
11K
(K)		RNA polymerase II subunit Jpolymer11713310.31UniProt (A0A8D0TE17)
Pfam (PF13656)		Sus scrofa (pig)
12L
(L)		RNA polymerase II subunit Kpolymer587018.21UniProt (A0A4X1TRS6)
Pfam (PF03604)		Sus scrofa (pig)
13M
(M)		Transcription elongation factor SPT6polymer1729199603.01UniProt (Q7KZ85)
Pfam (PF14632)
Pfam (PF14641)
Pfam (PF22706)
Pfam (PF14639)
Pfam (PF14635)
Pfam (PF17674)
Pfam (PF00575)
Pfam (PF14633)		Homo sapiens (human)hSPT6,Histone chaperone suppressor of Ty6,Tat-cotransactivator 2 protein,Tat-CT2 protein
14N
(N)		Non-template DNApolymer20663931.61synthetic construct
15O
(O)		Protein IWS1 homologpolymer82192235.91UniProt (Q96ST2)
Pfam (PF08711)		Homo sapiens (human)IWS1-like protein
16P
(P)		RNApolymer216535.81synthetic construct
17Q
(Q)		RNA polymerase-associated protein CTR9 homologpolymer1179134510.21UniProt (Q6PD62)
Pfam (PF13374)
Pfam (PF13181)		Homo sapiens (human)SH2 domain-binding protein 1
18R
(R)		RNA polymerase-associated protein RTF1 homologpolymer71380733.01UniProt (Q92541)
Pfam (PF03126)		Homo sapiens (human)
19S
(S)		Transcription elongation factor A protein 1polymer30434295.01UniProt (P23193)
Pfam (PF08711)
Pfam (PF07500)
Pfam (PF01096)		Homo sapiens (human)TFIIS
20T
(T)		Template DNApolymer21566097.21synthetic construct
21U
(U)		RNA polymerase-associated protein LEO1polymer66675514.21UniProt (Q8WVC0)
Pfam (PF04004)		Homo sapiens (human)Replicative senescence down-regulated leo1-like protein
22V
(V)		RNA polymerase II-associated factor 1 homologpolymer53160052.71UniProt (Q8N7H5)
Pfam (PF03985)		Homo sapiens (human)hPAF1,Pancreatic differentiation protein 2
23W
(W)		WDR61polymer30533617.51UniProt (Q9GZS3)
Pfam (PF00400)		Homo sapiens (human)
24X
(X)		Parafibrominpolymer53160673.51UniProt (Q6P1J9)
Pfam (PF16050)
Pfam (PF05179)		Homo sapiens (human)Cell division cycle protein 73 homolog,Hyperparathyroidism 2 protein
25Y
(Y)		Transcription elongation factor SPT4polymer12113508.51UniProt (P63272)
Pfam (PF06093)		Homo sapiens (human)hSPT4,DRB sensitivity-inducing factor 14 kDa subunit,DSIF p14,DRB sensitivity-inducing factor small subunit,DSIF small subunit
26Z
(Z)		Transcription elongation factor SPT5polymer1087121225.51UniProt (O00267)
Pfam (PF11942)
Pfam (PF03439)
Pfam (PF00467)		Homo sapiens (human)hSPT5,DRB sensitivity-inducing factor 160 kDa subunit,DSIF p160,DRB sensitivity-inducing factor large subunit,DSIF large subunit,Tat-cotransactivator 1 protein,Tat-CT1 protein
27AA, EA
(a, e)		Histone H3polymer13615437.12UniProt (A0A310TTQ1)
Pfam (PF00125)		Xenopus laevis (African clawed frog)
28BA, FA
(b, f)		Histone H4polymer10311394.42UniProt (P62799)
Pfam (PF15511)		Xenopus laevis (African clawed frog)
29CA, GA
(c, g)		Histone H2A type 1polymer13014109.42UniProt (P06897)
Pfam (PF00125)
Pfam (PF16211)		Xenopus laevis (African clawed frog)
30DA, HA
(d, h)		Histone H2B 1.1polymer12313655.92UniProt (P02281)
Pfam (PF00125)		Xenopus laevis (African clawed frog)H2B1.1
31IA
(l)		Histone-lysine N-methyltransferase SETD2polymer1133127887.31UniProt (Q9BYW2)
Pfam (PF08236)
Pfam (PF17907)
Pfam (PF00856)
Pfam (PF00397)		Homo sapiens (human)HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,Protein-lysine N-methyltransferase SETD2,SET domain-containing protein 2,hSET2,p231HBP
32JA, KA, MA, NA, OA...
(A, B, C, I, J...)		ZINC IONnon-polymer65.412Chemie (ZN)
33LA
(A)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence modifications
M: 1 - 1726 (UniProt: Q7KZ85)
PDBExternal DatabaseDetails
Ser -2-expression tag
Asn -1-expression tag
Ala 0-expression tag
O: 2 - 819 (UniProt: Q96ST2)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Ala 1-expression tag
Q: 1 - 1173 (UniProt: Q6PD62)
PDBExternal DatabaseDetails
Glu 1174-expression tag
Asn 1175-expression tag
Leu 1176-expression tag
Tyr 1177-expression tag
Phe 1178-expression tag
Gln 1179-expression tag
R: 1 - 710 (UniProt: Q92541)
PDBExternal DatabaseDetails
Ser -2-expression tag
Asn -1-expression tag
Ala 0-expression tag
S: 1 - 301 (UniProt: P23193)
PDBExternal DatabaseDetails
Ser -2-expression tag
Asn -1-expression tag
Ala 0-expression tag
Y: 1 - 117 (UniProt: P63272)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
a, e: 0 - 135 (UniProt: A0A310TTQ1)
PDBExternal DatabaseDetails
Met 36Lys 37engineered mutation
c, g: 0 - 129 (UniProt: P06897)
PDBExternal DatabaseDetails
Arg 99Gly 100conflict
Ser 123Ala 124conflict
d, h: 1 - 122 (UniProt: P02281)
PDBExternal DatabaseDetails
Met 0-initiating methionine
Thr 29Ser 33engineered mutation
l: 1435 - 2564 (UniProt: Q9BYW2)
PDBExternal DatabaseDetails
Ser 1432-expression tag
Asn 1433-expression tag
Ala 1434-expression tag
Leu 1962Pro 1962conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains35
Total formula weight1806983.4
Non-Polymers*Number of molecules13
Total formula weight809.2
All*Total formula weight1807792.6
*Water molecules are not included.

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PDB entries from 2025-06-11

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