9EF2
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin candidate 2, open conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-5 | polymer | 1005 | 109695.9 | 1 | UniProt (P08648) | Homo sapiens (human) | CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5 |
| 2 | B (B) | Integrin beta-1 | polymer | 738 | 81744.0 | 1 | UniProt (P05556) | Homo sapiens (human) | Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta |
| 3 | C (C) | NeoNectin candidate 2 | polymer | 99 | 11152.5 | 1 | synthetic construct | ||
| 4 | D, E, F (D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G (G) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 6 | H (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 7 | I, J, K (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 8 | L, M, N (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 9 | O, P, Q (B) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) |
Sequence modifications
A: -40 - 955 (UniProt: P08648)
B: -19 - 708 (UniProt: P05556)
| PDB | External Database | Details |
|---|---|---|
| Thr 956 | - | expression tag |
| Gly 957 | - | expression tag |
| Gly 958 | - | expression tag |
| Leu 959 | - | expression tag |
| Glu 960 | - | expression tag |
| Val 961 | - | expression tag |
| Leu 962 | - | expression tag |
| Phe 963 | - | expression tag |
| Gln 964 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 709 | - | expression tag |
| Thr 710 | - | expression tag |
| Ser 711 | - | expression tag |
| Gly 712 | - | expression tag |
| Leu 713 | - | expression tag |
| Glu 714 | - | expression tag |
| Val 715 | - | expression tag |
| Leu 716 | - | expression tag |
| Phe 717 | - | expression tag |
| Gln 718 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 202592.4 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2916.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 948.7 | |
| All* | Total formula weight | 206457.8 |
