9EEX

STEP (PTPN5) at high resolution with citrate bound in active site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein phosphatase non-receptor type 5	polymer	305	35204.8	1	UniProt (P54829) Pfam (PF00102)	Homo sapiens (human)	Neural-specific protein-tyrosine phosphatase,Striatum-enriched protein-tyrosine phosphatase,STEP
2	B (A)	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
3	C (A)	water	water		18.0	320	Chemie (HOH)

Sequence modifications

A: 258 - 539 (UniProt: P54829)

PDB	External Database	Details
Met 235	-	initiating methionine
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag
His 241	-	expression tag
Ser 242	-	expression tag
Ser 243	-	expression tag
Gly 244	-	expression tag
Val 245	-	expression tag
Asp 246	-	expression tag
Leu 247	-	expression tag
Gly 248	-	expression tag
Thr 249	-	expression tag
Glu 250	-	expression tag
Asn 251	-	expression tag
Leu 252	-	expression tag
Tyr 253	-	expression tag
Phe 254	-	expression tag
Gln 255	-	expression tag
Ser 256	-	expression tag
Met 257	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35204.8
Non-Polymers*	Number of molecules	1
	Total formula weight	192.1
All*	Total formula weight	35397.0

*Water molecules are not included.