9ED4
A composite map of mTORC1-Rag-Ragultor-4EBP1 on membrane
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, M (B, M) | Target of rapamycin complex subunit LST8 | polymer | 326 | 35910.1 | 2 | UniProt (Q9BVC4) Pfam (PF00400) | Homo sapiens (human) | TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8 |
| 2 | B, N (L, N) | GTP-binding protein Rheb | polymer | 184 | 20519.4 | 2 | UniProt (Q15382) Pfam (PF00071) | Homo sapiens (human) | Ras homolog enriched in brain |
| 3 | C, O (A, O) | Serine/threonine-protein kinase mTOR | polymer | 2549 | 289258.0 | 2 | UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF23593) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1 |
| 4 | D, P (D, P) | Ras-related GTP-binding protein A | polymer | 313 | 36600.2 | 2 | UniProt (Q7L523) Pfam (PF04670) | Homo sapiens (human) | Rag A,RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1 |
| 5 | E, Q (G, Q) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13517.5 | 2 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 6 | F, R (H, R) | Ragulator complex protein LAMTOR3 | polymer | 124 | 13637.7 | 2 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 7 | G, S (J, S) | Ragulator complex protein LAMTOR5 | polymer | 91 | 9622.9 | 2 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 8 | H, T (K, T) | Eukaryotic translation initiation factor 4E-binding protein 1 | polymer | 118 | 12593.0 | 2 | UniProt (Q13541) Pfam (PF05456) | Homo sapiens (human) | 4E-BP1,eIF4E-binding protein 1,Phosphorylated heat- and acid-stable protein regulated by insulin 1,PHAS-I |
| 9 | I, U (C, U) | Regulatory-associated protein of mTOR | polymer | 1335 | 149200.0 | 2 | UniProt (Q8N122) Pfam (PF14538) Pfam (PF02985) Pfam (PF00400) | Homo sapiens (human) | Raptor,p150 target of rapamycin (TOR)-scaffold protein |
| 10 | J, V (E, V) | Ras-related GTP-binding protein C | polymer | 399 | 44298.9 | 2 | UniProt (Q9HB90) Pfam (PF04670) | Homo sapiens (human) | RagC,GTPase-interacting protein 2,TIB929 |
| 11 | K, W (F, W) | Ragulator complex protein LAMTOR1 | polymer | 161 | 17762.8 | 2 | UniProt (Q6IAA8) Pfam (PF15454) | Homo sapiens (human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 12 | L, X (I, X) | Ragulator complex protein LAMTOR4 | polymer | 99 | 10753.2 | 2 | UniProt (Q0VGL1) | Homo sapiens (human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 13 | HA, Y (N, L) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 2 | Chemie (GSP) | |||
| 14 | BA, CA, FA, IA, KA... (A, D, N, O, P...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 15 | AA, JA (A, O) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 16 | DA, MA (A, O) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 17 | EA, NA (D, P) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 18 | GA, PA (E, V) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) |
Sequence modifications
D, P: 1 - 313 (UniProt: Q7L523)
E, V: 1 - 399 (UniProt: Q9HB90)
| PDB | External Database | Details |
|---|---|---|
| Leu 66 | Gln 66 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 75 | Ser 75 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 1307347.2 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 5538.2 | |
| All* | Total formula weight | 1312885.3 |
