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9ED1

Cryo-EM structure of the human KCa3.1/calmodulin channel in complex with Ca2+ and 1,4-dihydropyridine (DHP-103)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Intermediate conductance calcium-activated potassium channel protein 4polymer37842598.64UniProt (O15554)
Pfam (PF03530)
Pfam (PF07885)
Pfam (PF02888)
Homo sapiens (human)SKCa 4,SKCa4,hSK4,Gardos channel,IKCa1,hIK1,KCa3.1,Putative Gardos channel,hKCa4
2E, F, G, H
(E, F, G, H)
Calmodulin-1polymer14516406.04UniProt (P0DP29)
Pfam (PF13499)
Rattus norvegicus (Norway rat)
3I, J, K, L, M
(A, B)
POTASSIUM IONnon-polymer39.15Chemie (K)
4N, O, P, Q, R...
(E, F, G, H)
CALCIUM IONnon-polymer40.112Chemie (CA)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight236018.5
Non-Polymers*Number of molecules17
Total formula weight676.4
All*Total formula weight236695.0
*Water molecules are not included.

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PDB entries from 2025-06-18

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