9ECU
Crystal structure of the inactive BRAF/MEK1 complex bound to IK-595
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase B-raf | polymer | 284 | 32115.1 | 1 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | B (B) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 393 | 43493.9 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (human) | MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 3 | C, H (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | D, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | E, F, J, K (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | G (B) | 4-[2-chloro-3-(methylsulfamamido)phenoxy]-N-cyclopropyl-2-(2-fluoro-4-iodoanilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide | non-polymer | 675.9 | 1 | Chemie (A1BIS) | |||
| 7 | L, M (A, B) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 445 - 723 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 440 | - | expression tag |
| Gly 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Gly 443 | - | expression tag |
| Ser 444 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75609.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2121.2 | |
| All* | Total formula weight | 77730.2 |
