9EBI
Human adenosine A3 receptor Gi complex (mini-Gsi chimera) bound to Piclidenoson (CF101, IB-MECA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Adenosine receptor A3 | polymer | 363 | 41203.6 | 1 | UniProt (P0DMS8) Pfam (PF00001) | Homo sapiens (human) | |
| 2 | B (A) | mini-Gs/i chimera | polymer | 257 | 29057.9 | 1 | Homo sapiens | ||
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 349 | 38402.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (N) | Nb35 | polymer | 128 | 13885.4 | 1 | Lama glama | ||
| 6 | F (R) | Piclidenoson | non-polymer | 510.3 | 1 | Chemie (Q8L) PubChem (3668) PubChem (24867507) PubChem (44348940) PubChem (44396477) PubChem (123683) PubChem (68032325) PubChem (68225695) PubChem (92209839) PubChem (6603878) PubChem (6604809) PubChem (118705486) PubChem (139593367) PubChem (142745691) PubChem (11957586) PubChem (138107263) |
Sequence modifications
R: 2 - 318 (UniProt: P0DMS8)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp -36 | - | expression tag |
| Tyr -35 | - | expression tag |
| Lys -34 | - | expression tag |
| Asp -33 | - | expression tag |
| Asp -32 | - | expression tag |
| Asp -31 | - | expression tag |
| Asp -30 | - | expression tag |
| Ala -29 | - | expression tag |
| Ala -28 | - | expression tag |
| Asn -27 | - | expression tag |
| Phe -26 | - | expression tag |
| Thr -25 | - | expression tag |
| Pro -24 | - | expression tag |
| Val -23 | - | expression tag |
| Asn -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Ser -20 | - | expression tag |
| Ser -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Asn -17 | - | expression tag |
| Gln -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Val -14 | - | expression tag |
| Arg -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Val -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
| His 324 | - | expression tag |
| His 325 | - | expression tag |
| His 326 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 130279.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 510.3 | |
| All* | Total formula weight | 130790.1 |
