9EBI

Human adenosine A3 receptor Gi complex (mini-Gsi chimera) bound to Piclidenoson (CF101, IB-MECA)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	Adenosine receptor A3	polymer	363	41203.6	1	UniProt (P0DMS8) Pfam (PF00001)	Homo sapiens (human)
2	B (A)	mini-Gs/i chimera	polymer	257	29057.9	1		Homo sapiens
3	C (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	349	38402.9	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)	Transducin beta chain 1
4	D (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	70	7729.9	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
5	E (N)	Nb35	polymer	128	13885.4	1		Lama glama
6	F (R)	Piclidenoson	non-polymer		510.3	1	Chemie (Q8L)

Sequence modifications

R: 2 - 318 (UniProt: P0DMS8)

PDB	External Database	Details
Asp -36	-	expression tag
Tyr -35	-	expression tag
Lys -34	-	expression tag
Asp -33	-	expression tag
Asp -32	-	expression tag
Asp -31	-	expression tag
Asp -30	-	expression tag
Ala -29	-	expression tag
Ala -28	-	expression tag
Asn -27	-	expression tag
Phe -26	-	expression tag
Thr -25	-	expression tag
Pro -24	-	expression tag
Val -23	-	expression tag
Asn -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
Gly -18	-	expression tag
Asn -17	-	expression tag
Gln -16	-	expression tag
Ser -15	-	expression tag
Val -14	-	expression tag
Arg -13	-	expression tag
Leu -12	-	expression tag
Val -11	-	expression tag
Thr -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Leu -6	-	expression tag
Glu -5	-	expression tag
Val -4	-	expression tag
Leu -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Pro 1	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	130279.8
Non-Polymers*	Number of molecules	1
	Total formula weight	510.3
All*	Total formula weight	130790.1

*Water molecules are not included.