9E9D

Structure of full length AMPA receptor GluA2 and auxiliary subunit TARP gamma-2 in complex with anti-miR 17 oligonucleotide RGLS4326

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit	polymer	1028	114921.3	4	UniProt (P19491) UniProt (Q71RJ2)	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
2	E, F, G, H (A, B, C, D)	O-{[(1S,3S,4R,6S,7R)-7-{[(R)-{[(1R,3R,4R,6S,7R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methoxy}(sulfanyl)phosphoryl]oxy}-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methyl} O-[(2R,3S,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxy-2-methyloxolan-3-yl] hydrogen (R)-phosphorothioate	non-polymer		977.8	4	Chemie (A1BX3)

Sequence modifications

A, B, C, D: 10 - 998 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	conflict
Leu 382	Val 397	conflict
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	variant
Asp 385	Asn 406	variant
Gln 392	Asn 413	variant
Gly 999	-	linker
Thr 1000	-	linker

A, B, C, D: 1001 - 1207 (UniProt: Q71RJ2)

PDB	External Database	Details
Asp 1047	Asn 48	engineered mutation
Thr 1208	-	expression tag
Gly 1209	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	459685.2
Non-Polymers*	Number of molecules	4
	Total formula weight	3911.2
All*	Total formula weight	463596.4

*Water molecules are not included.